Resolving tooth development at single-cell resolution: advancing dental regeneration

Tooth development is a continuous, highly orchestrated process that serves as an ideal model for dissecting the cellular and molecular mechanisms of organogenesis. In recent years, advances in single-cell transcriptomics have provided unprecedented insights into cellular heterogeneity, lineage trajectories, and molecular signaling networks during mouse and human tooth development, greatly enhancing our understanding of odontogenesis. Crucially, these single-cell-level studies of tooth development provide both a theoretical foundation and advanced strategies for dental tissue regeneration.