Full text 2026

Methylome profiles to investigate gene regulation mediated by phase-variable DNA methyltransferases in serogroup B <i>Neisseria meningitidis</i>

Ascari A, Blakeway LV, Bentley SR, et al.

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Abstract

<i>Neisseria meningitidis</i> serogroup B is a major cause of meningitis and septicemia. Here, we report PacBio HiFi single-molecule real-time (SMRT) methylomics data sets for strains MC58, B6116/77, and M0579. These strains encode the phase-variable DNA methyltransferases ModA11, ModA12, and ModD1, respectively, which are epigenetic regulators pivotal to meningococcal pathogenicity.

Keywords

DNA methyltransferase Epigenetic regulation Phase variation Neisseria meningitidis Mod Pacbio Hifi Methylome Analysis