HT SpaceM enables high-throughput mapping of metabolic diversity at the single-cell level

Expanding metabolomic profiling to the single-cell level can reveal metabolic heterogeneity and clinically relevant subpopulations, yet existing methods lack sensitivity and scale. To address this gap, in a recent issue of Cell, Delafiori and colleagues introduce HT SpaceM, a high-throughput MALDI workflow enabling sensitive, reproducible, and scalable single-cell metabolomics.