Gut microbiotas attributed to disorders and diseases of the gastrointestinal tract, colorectal cancer, bladder cancer: Geographical factors, inflammation, metabolic toxic

Recently, there were several publications that attributed gut microbiota (GM) to various gastrointestinal tract functional disorders and diseases, including inflammatory bowel diseases, colon cancer, pancreatic cancer, and diverticulosis. GM is attributed to the initiation of urinary tract diseases and bladder carcinoma (BCa). The concern is whether GM is dysbiotic or protective. We explored the studies on GM contribution to colorectal cancer and BCa. Selected studies from different geographical regions on tissue samples or faecal samples from patients with colorectal cancer and controls. The results showed diverging results of microbiota abundance, genus, class, and phylum. These data indicated that other factors of environmental, diet, ethnic, and personal factors are contributors to GM in the initiation of inflammation and tumors. GM are not inhabitants in the urinary tract; it is postulated that GM attributes to BCa <i>via</i> the circulating metabolic toxins in the initiation of tumorigenesis and BCa.