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<h4>Background</h4>The patients with intrahepatic cholangiocarcinoma (iCCA) are highly susceptible to recurrence after radical resection, while predicting recurrence remains challenging. Adjacent-to-tumor tissues (ATTs), as the main microenvironment for postoperative recurrence, exhibited superior predictive value for recurrence …
Read PDFSelenium (Se) is an essential trace element for chickens that develops, through selenoproteins, important physiological functions. Although selenogen expression and Western blot analyses provided valuable information, there is a lack of information about the serum …
Read PDF<h4>Rationale</h4>Human hair shafts have received increased research interest owing to their easy accessibility and potential as a window for human health. Because the most abundant component in hair is protein, proteomics is a promising tool …
Read PDF<h4>Background</h4>There is an urgent need for the development of innovative diagnostic and therapeutic strategies in bladder cancer (BlCa) management, due to its significant incidence, mortality, and morbidity. Extracellular vesicles (EVs) constitute promising candidates as biomarkers, …
Read PDFThe increasing global burden of antimicrobial resistance (AMR) has been identified as a critical public health crisis, necessitating the development of robust, real-time surveillance frameworks to evaluate AMR dynamics. Sewage surveillance is emerging as a …
Read PDF<h4>Background</h4>Cardiomyopathies encompass a spectrum of myocardial disorders often attributed to underlying genetic mutations. However, genotype-phenotype discordance where the genetic profile does not align with the expected clinical presentation poses significant diagnostic, prognostic, and therapeutic challenges.<h4>Objective</h4>To …
Read PDFL1s are repetitive sequences capable of copying themselves into new genomic loci. While L1s are typically repressed by DNA methylation in somatic tissues, they can become reactivated in cancer. Although L1 sequences are highly repetitive, …
Read PDFIdentifying the genetic relatedness of resistant bacterial pathogens in healthcare settings can help identify undetected transmission events and outbreaks. However, current methods are time- and resource-intensive. We evaluated a rapid neighbor typing method paired with …
Read PDFMultidrug-resistant <i>Salmonella</i> has been classified as a pathogen of high priority. However, limited or mixed-quality studies reported multidrug-resistant <i>Salmonella</i> strains from pediatric patients. The study aimed to investigate the prevalence, serotypes, antimicrobial characteristics, and plasmid …
Read PDFAccurate cell type identification is critical for interpreting single-cell transcriptomic data and understanding complex biological systems. In this review, we discuss how natural language processing and large language models can enhance the accuracy and scalability …
Read PDFAggressive variant prostate cancer (AVPC) is a lethal subtype of prostate cancer characterized by androgen independence, resistance to chemotherapy, and neuroendocrine features that can emerge de novo or via transformation after a prior diagnosis of …
Read PDFPangenomes are revolutionizing our ability to resolve genomic regions with complex variations<sup>1</sup>. However, existing human pangenomes<sup>2,3</sup>, constrained by small sample sizes, provide limited utility for medical and population genetic applications. Here we generated 1,116 diploid …
Read PDFRecent advances in bioinstrumentation, such as the development of long-read sequencing, have reignited interest in methods for extracting long, intact nucleic acids from complex samples. One traditional method for this purpose is gel electrophoresis followed …
Read PDFAmerican sloughgrass [Beckmannia syzigachne (Steud.) Fernald] is a problematic annual grass weed in winter wheat fields of China, which causes great loss of wheat yield. A lack of high-quality genome resources has hindered understanding of …
Read PDF<b>Background/Objectives</b>: The Korean Global Antimicrobial Resistance Surveillance System monitors bloodstream <i>Staphylococcus aureus</i> infections by combining antimicrobial susceptibility testing (AST) with conventional polymerase chain reaction (PCR). Considering the clinical significance of methicillin-resistant <i>S. aureus</i> (MRSA), we …
Read PDFThis study presents the first complete mitochondrial genome of <i>Ferula sinkiangensis</i>, a medicinal plant formally recognized in the Chinese Pharmacopoeia since 1977. The assembled mitogenome is 416,958 bp in length, encoding 97 genes, and exhibits …
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