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All the studies of ketogenesis-dependent post-translational modifications (PTMs), notably those mediated by ketone bodies, β-hydroxybutyrate (Bhb) and acetoacetate (Acac), have focused on lysine acylations. However, given the chemically diverse and reactive nature of metabolites generated, …
Read PDFHuman leukocyte antigen (HLA) immunopeptidomics is restricted by the limited availability of allele-specific antibodies and by potential artifacts introduced by HLA overexpression systems. To address these challenges, we developed a CRISPR/Cas9-based strategy that selectively deletes …
Read PDFHere, we introduce Spectral Cruncher, an interactive extension to the PatternLab for Proteomics platform, designed to bridge the gap between manual curation and state-of-the-art computational analysis of proteomic tandem mass spectra. Spectral Cruncher integrates de …
Read PDFOver the past decade, the paradigm of molecular oncology has decisively shifted from a primarily gene-centric view to a deeply integrated, multi-omics perspective [...].
Read PDFIsovitexin (ISOV) is an active component identified in the traditional Tibetan medicine Tsantan Sumtang, which is commonly used for treating myocardial ischemia. Although previous studies have suggested the protective effect of ISOV on cardiomyocytes, the …
Read PDFSynbio milk, containing recombinant bovine β-lactoglobulin (β-LG), produced in the fungus Trichoderma reesei, was deficient nutritionally compared to bovine milk. It also contained both fungal proteins and fungal metabolites never verified safe for human consumption. …
Read PDF<h4>Background and objectives</h4>Increasing evidence indicates a potential role of white matter (WM) damage in the onset and progression of Alzheimer disease (AD). However, the biological processes underlying in vivo WM imaging biomarkers remain unclear. We …
Read PDF<h4>Objectives</h4>People with HIV (PWH) are at increased risk of cerebrovascular abnormalities, including aneurysmal subarachnoid hemorrhage (SAH). However, it is unclear whether HIV-associated inflammation contributes significantly to the inflammatory response observed in the cerebrospinal fluid (CSF) …
Read PDF<h4>Introduction</h4>Partly due to the inaccessibility of olfactory brain regions vulnerable to early Alzheimer's Disease (AD) for repeated sampling, proteomic networks underlying progressive cognitive decline remain poorly understood. The olfactory mucosa (OM), an accessible part of …
Read PDF<h4>Background</h4>Little is known regarding the expression patterns of adipose tissue proteins in the context of vitamin D deficiency and whether these expression patterns have adverse effects on fat-related diseases.<h4>Methods</h4>This study compares vitamin D receptor-knockout (VDRKO) …
Read PDFBACKGROUND: Polycystic ovary syndrome (PCOS) is associated with metabolism abnormalities and increased cardiovascular disease (CVD) risk. This study aimed to further investigate cardiovascular metabolism alterations specifically in the female offspring of PCOS patients using metabolomics …
Read PDF<h4>Purpose</h4>This study aims to provide a comprehensive bibliometric analysis of the literature on proteomics in neurodegenerative diseases in order to identify research trends, key contributors, and collaborative networks and to assess the field's development and …
Read PDFGenomics, metabolomics, and proteomics offer complementary insights into cardiovascular disease (CVD) risk. Leveraging UK Biobank data, we introduce the CardiOmicScore, a multitask deep learning framework, to learn disease-specific proteomic (ProScore) and metabolomic (MetScore) risk scores …
Read PDFIt is now recognized that mitochondria play a crucial role in tumorigenesis; however, it has become clear that tumor metabolism varies significantly between cancer types. The failure of recent clinical trials aimed at directly targeting …
Read PDFCross-kingdom microbial symbioses, such as those between algae and bacteria, are key players in biogeochemical cycles. The molecular changes during initiation and establishment of symbiosis are of great interest, but quantitatively monitoring such changes can …
Read PDF<h4>Introduction</h4>Sudden Unexpected Death in Epilepsy (SUDEP) refers to the unexplained, sudden death of individuals with epilepsy, and its incidence is closely linked to the severity and duration of seizures. This study aimed to identify plasma …
Read PDFMost existing transcriptome wide association studies (TWASs) of Alzheimer's Disease (AD) dementia only use bulk RNA-seq data and a single statistical method. Here, we utilize an omnibus TWAS (TWAS-O) pipeline that leverages multiple complementary statistical …
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