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The fecal immunochemical test (FIT) for detecting fecal occult blood, used alone or in combination with other stool biomarkers, has been demonstrated to be effective in the context of colorectal cancer (CRC) screening programs. However, …
Read PDFSpatial biology aims to elucidate cellular organization, function, and interactions within native tissue contexts, offering key insights into both normal physiology and disease. Spatial proteomics complements this by enabling high-resolution mapping of protein localization and …
Read PDFThe most common ocular neoplasia among children is retinoblastoma. Currently, the diagnosis of this disease is essentially clinical, taking a biopsy is contraindicated owing to the high risk of causing metastasis. Therefore, it is imperative …
Read PDFPathogenic mutations in Leucine-rich repeat kinase 2 (LRRK2) are the predominant genetic cause of Parkinson's disease (PD) and often increase kinase activity, making LRRK2 inhibitors promising treatment options. Although LRRK2 kinase inhibitors are advancing clinically, …
Read PDFAntimicrobial peptides (AMPs) are natural bioactive peptides produced by all organisms-from plants to insects, microbes and animals-and constitute a first line of defense. As they exhibit a broad spectrum of activity (antibacterial, antiviral, antifungal, antiparasitic, …
Read PDFMycobacteria have a hydrophobic cell envelope that makes uniform growth in liquid culture challenging. Non-ionic detergents, including Tween-80 and tyloxapol, are commonly added to media when culturing mycobacterial species in the laboratory. Tyloxapol was reported …
Read PDFThe nuclear envelope (NE) is a critical regulatory interface that preserves genome integrity and mediates nucleocytoplasmic transport, yet its compositional and functional landscape in plants remains poorly defined. Here, we present a multiomics atlas of …
Read PDF<h4>Purpose</h4>Uveal melanoma (UM), the most prevalent primary intraocular cancer in adults, is defined by salient histopathological diversity. Spindle and epithelioid cells constitute its two dominant pathological lineages, yet the latter foreshadows aggressive behavior and shortened …
Read PDFMass spectrometry-based spatial omics is a powerful approach for visualizing the spatial organization of proteins, metabolites, lipids, and other biomolecules in situ, combining the molecular depth of mass spectrometry with spatially resolved imaging. This systematic …
Read PDF<h4>Background</h4>Elderly sepsis (ES), characterized by dual insults of aging and sepsis, is associated with substantial morbidity and mortality and exhibits distinct pathophysiological features. Elucidating these unique mechanisms is critical for developing precise therapeutic strategies and …
Read PDFAll plants and animals form symbiotic associations with microbes, yet many of the underlying mechanisms associated with these interactions remain uncharacterized. There are inherent challenges to studying the cellular and metabolic interactions between eukaryotes and …
Read PDFPostprandial variability in glucose and protein levels is one of the elements of insulin resistance (IR) and prediabetes, which is an area precursor to type 2 diabetes mellitus (DM). The objective of the study was …
Read PDFCervical cancer (CC) represents a leading malignant threat to women’s health globally. Patients with advanced-stage CC frequently encounter limited therapeutic efficacy and prominent drug resistance, highlighting the urgent need for molecular-driven precision treatment strategies. Herein, …
Read PDFPlastic microfibers (PMFs) increasingly accumulate in wastewater treatment plants, impairing sludge dewatering and raising operational costs. This study combines a bibliometric analysis (2000-2025) with a critical review of the recent mechanistic literature to map the …
Read PDFEarly embryonic development requires tightly regulated molecular programs to coordinate cell division, fate specification, and spatial patterning. While transcriptomic profiling has been widely performed, proteomic analyses of early vertebrate embryos remain limited owing to technical …
Read PDFContinuous directed evolution is a powerful Synthetic Biology tool to engineer proteins with desired functions <i>in vivo</i>. Mimicking natural evolution, it involves repeated cycles of high-frequency mutagenesis, selection, and replication within platform cells, where the …
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