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Ischemic stroke is a complex, multifactorial disorder with a significant heritable component. Recent developments in genome-wide association studies (GWASs) have identified several common variants associated with clinical outcomes, stroke subtypes, and overall risk. Key loci …
Read PDFGlucocorticoids are primary stress hormones necessary for life that act on nearly every tissue in the body to maintain homeostasis. These hormones and their synthetic derivatives are widely used in the clinic to combat disease …
Read PDFThe impact of diet during pregnancy on birth outcomes and child health is well established, and epigenetic changes may be one mechanism underlying such associations, but the role of meal timing (chrono-nutrition) is unclear. We …
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Read PDFThe elucidation of actionable, tumor-specific neoantigens remains a challenge in cancer immunotherapy. We identify <i>FGGY</i>-204, an alternatively spliced isoform of <i>FGGY</i>, as a source of tumor-specific neoantigen presentation. <i>FGGY</i>-204 expression is elevated in HCC and …
Read PDF<b>Background:</b> Accurate identification of cancer driver genes is essential for understanding tumorigenesis and developing targeted therapies. Although graph neural networks (GNNs) have advanced multi-omics integration, existing methods often simply concatenate omics features and underutilize the …
Read PDFPioneer transcription factors (TF) bind nucleosome-embedded DNA motifs to activate new regulatory elements and promote differentiation. However, the complexity, binding dependencies and temporal effects of their action remain unclear. Here, we dissect how ectopic induction …
Read PDFCancer stem cells (CSCs) represent a critical subpopulation within tumors, driving malignancy, metastasis, and therapeutic resistance. Their unique biological attributes, particularly the distinctive landscape of surface glycans and glycoproteins, offer promising avenues for targeted therapeutic …
Read PDFMajor depressive disorder (MDD) is a highly prevalent and heterogeneous psychiatric disorder shaped by the interplay of genetic, environmental, and epigenetic factors. Histone modifications, particularly acetylation and methylation, have emerged as critical regulators of chromatin …
Read PDFNeuropsychiatric interest in the relationship between glucose metabolism and criminal behavior dates back nearly a century. In particular, hypoglycemia was thought to play a causative role in some criminal acts, especially non-planned incidents involving impulsivity …
Read PDF<h4>Motivation</h4>5-Hydroxymethylcytosine (5hmC), a crucial epigenetic mark with a significant role in regulating tissue-specific gene expression, is essential for understanding the dynamic functions of the human genome. Despite its importance, predicting 5hmC modification across the genome …
Read PDF<h4>Background/aim</h4>Loss of smell, also known as anosmia, is a prevalent and often prolonged symptom following infection with SARS-CoV-2. While many patients regain olfactory function within weeks, a significant portion experience persistent anosmia lasting over a …
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Read PDFCoronary Artery Disease (CAD), mainly due to the progressive development of atherosclerotic plaques, is one of the world's leading causes of mortality and morbidity. A significant percentage of initial events (around 30%) remain fatal to …
Read PDFCardiovascular diseases (CVDs) are the leading causes of morbidity and mortality worldwide. Yet, drug discovery for these conditions faces significant challenges due to the complexity and heterogeneity of their underlying pathology. Recently, artificial intelligence (AI) …
Read PDF<h4>Background</h4>The Multi-Omics for Mothers and Infants (MOMI) Consortium aims to define biological mechanisms associated with preterm birth, small for gestational age, preeclampsia, and stillbirth. Globally, the burden of adverse pregnancy outcomes (APOs) is highest in …
Read PDFGastroenteropancreatic neuroendocrine tumours (GEP-NETs) are commonly treated with radio-ligand therapy (RLT) but reliable biomarkers for predicting early disease progression are lacking. In this exploratory study we investigated whether microRNA (miRNA) expression in archival samples is …
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