Search the literature by keyword, topic, or author. Filter to articles with full text available.
10021 results
Maternal immune activation during pregnancy has been associated with abnormal infant neurodevelopment. During the COVID-19 pandemic, we enrolled pregnant individuals with laboratory-confirmed SARS-CoV-2 infection into a cohort study conducted in Los Angeles, United States, and …
Read PDFPrecise differentiation between closely related species is crucial for effective clinical diagnosis and treatment. <i>Haemophilus influenzae</i> and <i>Haemophilus aegyptius</i> are phenotypically similar but differ in pathogenic potential, with <i>H. influenzae</i> involved in respiratory and invasive …
Read PDFDDX3X, a DEAD-box RNA helicase, has been identified as a risk gene for autism spectrum disorder (ASD). To elucidate the role of DDX3X mutations in ASD pathogenesis, HT22 cell models and mouse models with Ddx3x …
Read PDF<h4>Introduction</h4>Few genetic studies on Alzheimer's disease (AD) have incorporated multiple ancestries and omic datasets to pinpoint actionable AD risk effectors for each ancestry.<h4>Methods</h4>Here, we first performed genetic colocalization between molecular phenotypes (proteomics and metabolomics) from …
Read PDFThis Data Descriptor presents a comprehensive LC-MS/MS-based muscle proteome dataset for Clarias magur subjected to sustained sub-lethal thermal stress. Fish were maintained at a control temperature of 26 °C or gradually warmed at a rate …
Read PDFBoth the Apolipoprotein E (ApoE) genotype and apolipoprotein (Apo) profiling are closely associated with the risk of coronary heart disease (CHD). However, it remains unclear whether APOE genotypes modulate the distribution of Apos and whether …
Read PDF<h4>Objective</h4>Meningioma is the most common primary brain tumour. Invasion into the brain is a diagnostic feature of grade II meningiomas and is associated with recurrence and poor prognosis. Mebendazole is a microtubule inhibitor typically prescribed …
Read PDF<h4>Background</h4>The growing prevalence of cardiovascular diseases (CVDs) has created an increasing demand for alternative biologically functional vascular grafts. Among the explored tissue engineering strategies, decellularization provides a means to generate suitable acellular scaffolds from donor …
Read PDF<h4>Background</h4>Small cell lung cancer (SCLC) is an aggressive neuroendocrine tumor characterized by rapid progression, early metastasis, and high mortality, with limited effective long-term treatment options. <i>B4GALT1</i>, a β-1,4-galactosyltransferase, has been implicated in the malignant progression …
Read PDF<h4>Background</h4>Formalin-fixed paraffin-embedded (FFPE) tissue proteomics has emerged as a promising approach for precision medicine, offering access to vast clinical archives. Despite technological advances enabling identification of thousands of proteins from FFPE samples, no proteomic diagnostic …
Read PDFGlycosaminoglycans (GAGs) and their degrading enzymes have extensive applications and biotechnology and medicine, and play a crucial role in the recycling of organic matter in oceans. In this study, a potential GAG utilization gene cluster …
Read PDF<h4>Purpose</h4>The purpose of this study was to determine how Pax6 haploinsufficiency alters epithelial maturation, immune balance, sensory innervation, and lacrimal function across the ocular surface, and how these defects affect corneal repair.<h4>Methods</h4>Pax6tm1Ued mice crossed with …
Read PDFViral proteases are essential enzymes in many viral strains, playing a crucial role in the viral replication cycle. They are key targets for antiviral drug development and have significant implications for viral pathogenesis. To address …
Read PDFHigh-throughput proteomic profiling provides a comprehensive analysis of systemic cancer effects and tumor microenvironment interactions. Characterizing soluble proteins driving inflammation in acute myeloid leukemia (AML) offers insight into inflammatory diseases like differentiation syndrome related to …
Read PDFThe cellular secretome is a rich source of biomarkers and extracellular signaling molecules, but proteomic profiling remains challenging, especially when processing culture volumes greater than 5 mL. Low protein abundance, high serum contamination, and sample …
Read PDFSingle-cell proteomics (scP) is a crucial complement to transcriptomics, offering deeper insight into cellular heterogeneity, disease mechanisms, and therapeutic vulnerabilities in samples such as 2D cell culture, 3D models, and patient tissue. While transcriptomics enables …
Read PDFPhenotyping cells at transcriptomic and proteomic levels is an essential step to understanding cellular contributions to development, aging, injury, and disease. Since proteome and transcriptome level abundances modestly correlate, complementary profiling of both is needed. …
Read PDFThe airway epithelium is the first site of injury from cigarette smoke (CS), a major risk factor for chronic lung disease including idiopathic pulmonary fibrosis (IPF). Here, we report the first intracellular proteomic analysis of …
Read PDFProteomic experiments, particularly those addressing dynamic proteome properties, time series, or genetic diversity, require the analysis of large sample numbers. Despite significant advancements in proteomic technologies in recent years, further improvements are needed to accelerate …
Read PDFNo abstract available.
Read PDF