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Antibiotic resistance is a major threat to global public health. It is vital to understand the mechanism of antibiotic resistance development to prevent the emergence of new pan-resistant pathogenic bacteria and to develop new antibiotics. …
Read PDFSubcellular proteomics maps protein localization within restricted domains of a cell, complementing high-resolution imaging by expanding the number of proteins that can be profiled at once. Achieving this at depth from subcellular inputs remains challenging. …
Read PDFThe aim of this study was to investigate the effect of sodium lactate (SL) on the gel quality of cold-stored <i>L.</i> <i>vannamei</i> and its underlying mechanism. Fresh <i>L.</i> <i>vannamei</i> were soaked in 1%, 2%, 3% …
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Read PDFGlaucoma, a leading cause of irreversible visual impairment, is driven by progressive retinal ganglion cell (RGC) degeneration. Emerging evidence highlights astrocytes as pivotal players in its pathogenesis, with their heterogeneity and pathological metabolic reprogramming profoundly …
Read PDF<h4>Introduction</h4>Men generally have higher plasma uric acid (PUA) concentrations and are at greater risk for hyperuricemia-related diseases. Sex hormones may underlie this difference, though mechanisms remain unclear. Sex hormone therapy offers a unique opportunity to …
Read PDFDupuytren's disease is a fibroproliferative disorder of the palmer fascia (PF) characterised by flexion contractures in the hand. Dupuytren's disease can be treated surgically, but disease recurrence rates are high, potentially due to continual production …
Read PDFHuman embryonic stem cells (hESCs) provide a powerful in vitro model to study lineage specification and the regulatory programs underlying early human development. Here, we present a high-resolution, temporal multi-omics dataset tracking mRNA, translation, and …
Read PDFDiabetic nephropathy (DN) represents the predominant microvascular complication associated with diabetes mellitus; however, existing diagnostic techniques are inadequate. This study evaluated candidate urinary protein biomarkers for diagnosing DN. A cohort comprising 59 patients with type …
Read PDFAcute myeloid leukemia (AML) remains challenging to treat due to extensive genetic heterogeneity, high relapse rates, and treatment-related toxicity. Although drug combinations offer therapeutic promise, their selection is often empirical. Here, we introduce Combinatorial Proteome …
Read PDFThe LIM kinases (LIMK1/2) are key mediators in signaling cascades that regulate actin cytoskeleton dynamics via cofilin phosphorylation. Dysregulation of these pathways and overexpression of LIMKs are implicated in disease development, including cancer, Fragile X …
Read PDFKinase inhibitors represent a vital class of therapeutic agents widely used in cancer research, immunology, and other disease areas. Mass spectrometry (MS) employing specially designed small-molecule kinase-binding probes has become an essential strategy for identifying …
Read PDFPleural Mesothelioma (PM) is an aggressive cancer that attacks thousands of people every year. One of the common treatments is surgery to remove the tumor. Unfortunately, around 11% of patients die from blood clots post-surgery. …
Read PDFPSLite Online is a modern, web-based application designed to facilitate the analysis of top-down mass spectrometry fragmentation data, particularly for targeted proteoform studies. As a successor to the Windows-only ProSight Lite, PSLite Online retains and …
Read PDFAspirin (Asp) therapy reduces the risk of arterial thrombotic events. However, aspirin-related adverse effects, particularly cerebral hemorrhage with its high mortality and disability rates, remain a significant concern. Interestingly, long-term antiplatelet therapy does not appear …
Read PDFInsulin resistance (IR) links obesity to metabolic disorders. While weight loss reverses IR, we show that calorie reduction (CR) can do so in obese mice within a day before significant weight loss. In contrast to …
Read PDFType 1 diabetes is caused by autoimmune destruction of insulin-secreting β-cells within islets of Langerhans. Transplantation of donor islets can improve glycaemic control, but current clinical islet transplantation protocols are compromised by extensive loss of …
Read PDFObesity, sarcopenia, malnutrition, and cachexia all include assessment of body composition in their respective clinical guidelines, although patient evaluations frequently require hardware that may not be available. Body mass index often fills this void, but …
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