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<h4>Objective</h4>Intervertebral disc degeneration (IDD) imposes substantial economic and healthcare burdens, yet its mechanisms remain incompletely understood and effective pharmacological treatments are lacking. This study aimed to elucidate key factors driving IDD progression, specifically investigating lysosomal …
Read PDFWhile LC retention time prediction of peptides and their modifications has proven useful, widespread adoption and optimal performance are hindered by variations in experimental parameters. These variations can render retention time prediction models inaccurate and …
Read PDFLow-flow liquid chromatography has become the primary tool for advanced chromatographic analysis and is an indispensable technique for the sensitive detection of biomolecules. In this study, we developed a new 4-tritylphenyl methacrylate-based monolithic nano-column with …
Read PDFMetabolic reprogramming is a hallmark of myocardial infarction (MI), in which cardiomyocytes shift from fatty acid oxidation to anaerobic glycolysis, leading to elevated lactate production and mitochondrial dysfunction. Lactylation, a recently discovered lysine post-translational modification, …
Read PDF<h4>Background</h4>Cholangiocarcinoma (CCA) is a rare cancer, with limited understanding of genetic and prognostic determinants. We aimed to explore genetic risk factors, assess their prognostic implications and evaluate associated systemic and intratumoral features.<h4>Methods</h4>We screened the UK …
Read PDFThe present work proposes a reproducible and automated workflow for integrating digital pathology in matrix-assisted laser-desorption ionization mass spectrometry imaging (MALDI-MSI) data analysis, using thyroid tissue as a proof-of-concept application. MALDI-MSI has shown promise in …
Read PDFSome hibernating species, such as the brown bear (Ursus arctos), can endure several months of physical inactivity and fasting without suffering the typical deterioration observed in inactive or starved non-hibernators, such as muscle atrophy, bone …
Read PDFLysine methylation is a regulatory post-translational modification with diverse roles across both histone and non-histone proteins. Despite its biological relevance, comprehensive characterization of lysine methylation remains analytically challenging due to its low stoichiometry, subtle mass …
Read PDFBiomarker research relies on venous blood sampling, which demands trained professionals and proper sample handling, presenting challenges for both rural health care providers and large-scale studies. This study aims to investigate the use of dried …
Read PDFThe biological functions of extracellular vesicles (EVs) depend on their cellular source. Further, different subpopulations of EVs from the same cells carry different cargo, but differences in their biological functions are less understood. We here …
Read PDFCopyright: © 2026 Polykretis et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0), which permits unrestricted use, distribution, and reproduction in any medium, …
Read PDFExtracellular vesicles (EVs) play an important role in cancer progression and metastasis. The increasing clinical proteomics data provides an opportunity to uncover new biomarkers and therapeutic targets in cancer specific EVs. Here, we present an …
Read PDFProteomics captures the biological and functional state of cells, condensing complex molecular information into quantitative measurements, yet the reuse of public mass spectrometry (MS) data is impeded by heterogeneous processing and incomplete metadata, limiting its …
Read PDFThe reasons why two multiprotein complexes - VPS34 complex I and VPS34 complex II - are activated by different Rab proteins are becoming clearer.
Read PDFBACKGROUND: The uterus is a pivotal organ for mammalian reproduction, directly determining reproductive success by orchestrating embryo implantation, placental development, fetal nourishment, and parturition. However, the molecular mechanisms regulating high fecundity in the uterus across …
Read PDF<b>Background:</b> Asthma involves chronic inflammation linked to metabolic reprogramming, but how metabolites reshape epigenetics through posttranslational modifications remains unclear. <b>Methods:</b> We used house dust mite (HDM)-induced asthmatic mice with multiomics analyses (metabolomics, posttranslational modification-proteomics, and …
Read PDFChronic sleep insufficiency is prevalent in modern society and has been associated with age-related neurodegenerative diseases. Sleep loss accelerates neurodegeneration in animal models. Here, we study whether chronic sleep curtailment leads to brain aging in …
Read PDF<h4>Purpose</h4>To evaluate whether extending the postmortem interval (PMI) from 12 to 18 hours affects transcript and protein abundances in the human retina.<h4>Methods</h4>Donor eyes were recovered from postmortem donors (n = 7 pairs) and stored at …
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