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<b>Background</b>: Timely screening and diagnosis are critical for improving prognosis and survival in gastric cancer. Building on prior serum proteomics findings, this study evaluated two novel early-stage diagnostic biomarkers, CFL1 and TAGLN2, using retrospective and …
Read PDFGlobal environmental change affects organisms, including their physiology. In freshwater ecosystems, where migration is limited, populations often rely on phenotypic plasticity to respond. While transcriptomics has been widely used to study stress responses at the …
Read PDFCancer biomarkers are now recognized as major tools for early detection, diagnosis, and prognosis. In the last 10 years or so, molecular biology, proteomics, and genomics have been rapidly advancing to find tissue-specific biomarkers used …
Read PDFFeline calicivirus (FCV) is a highly variable RNA virus that infects domestic cats and circulates endemically within feline populations, causing a wide spectrum of clinical manifestations, from asymptomatic infections to severe disease. Genomic analysis of …
Read PDFTranslational errors (TEs) result in a mismatch between mRNA codons and the amino acids (AAs) of the corresponding protein. Unlike DNA mutations or RNA editing, where nucleotide sequences can be used to infer AA substitutions, …
Read PDFBACKGROUND: Plasma and cerebrospinal fluid are complementary sources of biomarkers for neurodegenerative diseases. The wide dynamic range of protein abundances, particularly in plasma, hampers detection of low-abundance proteins. Depletion of high-abundance proteins and efficient enzymatic …
Read PDFThe Epstein-Barr virus (EBV) is a human gamma-herpesvirus which infects over 90% of the global population and is associated with lymphoid and epithelioid cancers. After infection, EBV enters a latent state in B cells, whereby …
Read PDFImmunotherapy offers promising opportunities to improve immune-mediated control of chronic myeloid leukemia (CML), but its success depends on identifying antigens uniquely associated with CML. Protein kinases regulate signaling and protein turnover, influencing which peptides are …
Read PDFTo assess the potential for high resolution ion mobility (HRIM) as an alternative means of precursor isolation for mass spectrometry fragmentation analysis we performed a meta-analysis of predicted tryptic peptide features from the human proteome …
Read PDFSelective protein terminal labeling has become essential for system-wide studies of proteolytic mechanisms in disease. These methods enable precise tracking of cleavage dynamics, protease interactions, and cellular networks, offering transformative potential for proteolytic event analysis. …
Read PDFDiabetic peripheral neuropathy (DPN) is a common complication of diabetes and there are currently no biomarkers for DPN in clinical practice. The objective of this study was to explore the diagnostic value of urine for …
Read PDFThe BioSamples database (https://www.ebi.ac.uk/biosamples/) at the European Bioinformatics Institute (EMBL-EBI) is a core infrastructure resource that provides a centralized platform for the storage, curation, and dissemination of biological sample metadata. BioSamples holds sample descriptions across …
Read PDFBiological nanoscale assemblies transfer proteins and RNAs between cells and cellular compartments. Nonetheless, it is unclear if exogenous and synthetic nanostructures affect these molecular assemblies and processes. Here we report nanostructure-biological hybrid complexes that are …
Read PDF<h4>Background</h4>Establishing continuous cell lines is hindered by limited molecular resolution of culture establishment and the transition to sustained proliferation. Here, proteome changes across passages were quantified in two independently derived California grunion (Leuresthes tenuis) embryonic-derived …
Read PDFThis study aimed to elucidate the effects and underlying mechanisms of Abrus cantoniensis in treating mice hepatic fibrosis, thereby providing a rationale for its clinical application. To investigate A. cantoniensis effects in hepatic fibrosis, we …
Read PDFBull fertility impacts herd fertility, but accurately predicting male fertility from sperm characteristics is difficult once extremes are removed. The objectives of this study were identification, relative quantification, and comparison of sperm head plasma membrane …
Read PDFHigh-throughput sequencing enables genome-wide interrogation of biological systems, yet prioritizing functionally relevant genes and proteins from these data remains a key challenge. Here, we present ExIR (experimental data-based integrative ranking), a data-driven framework that classifies …
Read PDF<h4>Background</h4>PGM1-congenital disorder of glycosylation (PGM1-CDG) is frequently associated with cardiomyopathy. Although galactose therapy corrects glycosylation defects, cardiac dysfunction typically persists, suggesting a glycosylation-independent mechanism. Recent evidence of mitochondrial abnormalities in PGM1-deficient human and murine heart, …
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