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Ubiquitination serves as a key regulatory mechanism in nearly all cellular processes, though it was originally identified as a post-translational modification that targets proteins for degradation. Accordingly, these two molecular events have since been tightly …
Read PDFEwing sarcoma (EWS), a rare pediatric bone tumor, poses unique therapeutic challenges due to its distinct microenvironment and limited molecular understanding. To gain a comprehensive molecular and functional view of the tumors in their microenvironment, …
Read PDF<h4>Background</h4>Host cell proteins (HCPs) are process-related impurities that must be monitored in biopharmaceutical products due to their potential impact on product quality and patient safety. Targeted LC-MS/MS approaches such as multiple reaction monitoring (MRM) enable …
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Read PDFAlthough Dupuytren's disease (DD) and relapsed Clubfoot (RC) are clinically distinct conditions, both exhibit fibrotic tissue remodeling and contracture. This exploratory study investigated whether DD and RC share molecular features associated with fibroproliferative contracture. Pathological …
Read PDF<h4>Background</h4>Kawasaki disease (KD) is a leading cause of acquired heart disease in children, with coronary artery lesions (CAL) as its most severe complication. This observational study aimed to investigate the expression of bone marrow stromal …
Read PDFGluten proteins are key components in wheat flour that determine the formation of dough and the quality of flour-based products. Upon hydration and mixing, gluten proteins undergo complex structural transformations to form a gluten network, …
Read PDFGenomics and epigenomics outline potential cellular changes, while proteomics reflects actual molecular events. To systematically bridge the molecular hierarchies and validate their functional interplay, we established the most comprehensive pan-cancer paired multi-omics resource to date, …
Read PDFData-Dependent Acquisition (DDA) and Data-Independent Acquisition (DIA) are widely used in MS-based proteomics. However, a comprehensive evaluation of their data characteristics-including protein and peptide identification, differential expression analysis, and the performance in revealing biological insights-remains …
Read PDF<h4>Background</h4>Current understanding of transporter protein expression and localization within the neurovascular unit (NVU) of the human normal brain cortex and glioblastoma (GBM) remains largely qualitative and lacks cellular resolution. This study aimed to provide a …
Read PDFAchieving minimally invasive and rapid detection is a crucial goal in modern medicine. The comprehensive characterization of the blood proteome holds great promise in advancing our understanding of disease etiology, facilitating early diagnosis, risk stratification, …
Read PDFProteomics utilizes tandem mass spectrometry (MS/MS) to determine peptide sequences, traditionally through database searches constrained by prior knowledge. De novo sequencing offers a database-free alternative but struggles with accurately modeling complex MS/MS spectra. Most current …
Read PDFIdiopathic pulmonary fibrosis (IPF) is a chronic, rare, and fatal disease that is the consequence of aberrant remodeling and defective repair mechanisms within the lung, culminating in the loss of alveolar integrity. Although significant progress …
Read PDFThe intensification of pig (<i>Sus scrofa domesticus</i>) production systems raises concerns regarding animal welfare, particularly during pre-slaughter conditions, a phase associated with significant stress. Saliva is increasingly recognised as a non-invasive matrix for detecting stress-related …
Read PDF<b>Aim:</b> Extracellular vesicles (EVs) contribute to stroke rehabilitation by mediating intercellular signaling during inflammation and tissue repair. Here we report EV-associated surface proteins as potential biomarkers for predicting recovery of activities of daily living (ADL) …
Read PDF<h4>Introduction</h4>Proteins interacting with amyloid beta (Aβ) fibrils could be key to plaque formation in Alzheimer's disease (AD) and represent potential biomarkers and therapeutic targets. Previous proteomic studies using microdissected plaques might have captured non-specific components …
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