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<h4>Motivation</h4>Multi-omics data, i.e. genomics, epigenomics, transcriptomics, proteomics, characterize cellular complex signaling systems from multi-level and multi-view and provide a holistic view of complex cellular signaling pathways. However, it remains challenging to integrate and interpret multi-omics …
Read PDF<b>Background/Objectives</b>: Metabolic dysfunction-associated steatotic liver disease (MASLD) is rapidly attracting growing concern around the world. While there has been progress in the development of pharmacologic treatments, lifestyle and dietary interventions remain as the first-line approach …
Read PDFDNA foundation models trained on large-scale genomic and epigenetic datasets have shown promise for regulatory variant interpretation, yet their application to tissue-specific contexts remain limited. Here, we present a transfer learning (TL) framework to adapt …
Read PDFThe development of vaccines against viral infections has advanced rapidly over the past century, propelled by innovations in laboratory and molecular technologies. These advances have expanded the range of vaccine platforms beyond live-attenuated and inactivated …
Read PDF<h4>Background</h4>Pediatric AML prognosis research has advanced significantly, yet gaps in understanding genetic and molecular interactions persist. Despite improved outcomes, relapse/refractory cases and personalized treatment integration remain critical clinical challenges.<h4>Objective</h4>To analyze the global research landscape on …
Read PDFAmyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by the progressive loss of upper and lower motor neurons, leading to muscle weakness, paralysis, and ultimately respiratory failure. Despite advances in understanding its genetic …
Read PDF<h4>Motivation</h4>Spatially resolved chromatin accessibility profiling offers the potential to investigate gene regulatory processes within the spatial context of tissues. However, current methods typically work at spot resolution, aggregating measurements from multiple cells, thereby obscuring cell-type-specific …
Read PDFClass IIa histone deacetylases (HDACs) are pleiotropic regulators of various differentiation pathways and adaptive responses. They form complexes with other co-repressors and can bind to DNA by interacting with selected transcription factors, with members of …
Read PDFThe significance of gut microbiota in human health has gained increasing attention. Accordingly, metabolomics has been used to elucidate host-microbiota interactions. Liquid chromatography-tandem mass spectrometry (LC-MS/MS) is an ideal choice for metabolome analysis of gut …
Read PDFOmics approaches have significantly contributed to our understanding of several aspects of chicken reproduction. This review paper gives an overview of the use of omics technologies such as genomics, transcriptomics, proteomics, and metabolomics to elucidate …
Read PDFAltered histone post-translational modifications are frequently associated with cancer. Here, we apply mass-spectrometry to study the epigenetic landscapes of breast cancer subtypes, with a particular focus on triple-negative breast cancers (TNBCs), a heterogeneous group lacking …
Read PDF<h4>Background</h4>Gastrointestinal (GI) malignancies, including gastric and colorectal cancers, remain one of the primary contributors to cancer-related illness and death globally. Despite the availability of conventional diagnostic tools, early detection and personalized treatment remain significant clinical …
Read PDFBACKGROUND: Disentangling physiopathological mechanisms of biological systems through high-level integration of omics data has become a standard procedure in life sciences. However, platform heterogeneity, batch effects, and the lack of unified methods for single- and …
Read PDFA subset of long-term smokers remain free of chronic obstructive pulmonary disease or lung cancer, a phenomenon termed "lung resilience." Understanding this resilience could reveal protective mechanisms that preserve respiratory health, yet conceptual and methodological …
Read PDF<b>Background:</b> This genetic association study investigated single nucleotide polymorphism (SNP) in interleukin-8 (<i>CXCL8</i>) and opiorphin (<i>OPRPN</i>) genes, as well as psychological characteristics and oral behaviours, between patients with pain-related temporomandibular disorders (TMDp) and healthy controls. …
Read PDFB cell malfunction is implicated in the pathogenesis of systemic lupus erythematosus (SLE) through the release of proinflammatory cytokines and the production of autoreactive antibodies. RNA N<sup>6</sup>-methyladenosine (m<sup>6</sup>A) is the predominant post-transcriptional RNA modification that …
Read PDFChromatin accessibility is crucial in regulating gene expression and maintaining cellular identity. While single-cell RNA sequencing has revolutionized transcriptomic profiling, the understanding of chromatin dynamics across diverse tissues remains limited. Here, we use single-cell Assay …
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