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Cytidine to uridine (C-to-U) as well as adenosine to inosine (A-to-I) RNA editing denotes the posttranscriptional modification of RNA by specialized RNA deaminases. As RNA editing alters the sequence of the RNA, it can affect …
Read PDFIntestinal protists are emerging as key modulators of host immunity and microbial ecology, yet their impact on mammalian hosts remains poorly defined. Here, we investigated the role of two distinct protists, the amoeba <i>Entamoeba muris</i>, …
Read PDFAlveolar macrophages (AMs) are key mediators of lung function and are potential targets for therapies during respiratory infections. TGFβ is an important regulator of AM differentiation and maintenance, but how TGFβ directly modulates the innate …
Read PDFβ-Barrel outer membrane proteins (OMPs) perform critical functions in gram-negative bacteria including outer membrane biogenesis, nutrient acquisition, and efflux. OMPs are folded by the β-barrel assembly machinery (BAM) with BamA as a central and essential …
Read PDF<h4>Introduction</h4>The airway epithelial barrier continues to develop during the first year of life, representing a critical time window of susceptibility to the effects of respiratory viruses that may contribute to the development of childhood asthma. …
Read PDFEarly B-cell development is primarily regulated at the transcriptional level and comprises the consecutive differentiation stages B-cell progenitor, pro-B-cell and pre-B-cell. These entities provide the cells of origin in B-cell precursor acute lymphoid leukemia (BCP-ALL) …
Read PDFMicroscopic vascular invasion (VI) predicts recurrence and benefit from lobectomy in stage I lung adenocarcinoma (LUAD) but cannot be accurately predicted before surgery. Thus, biomarkers that identify this aggressive tumor subset are needed. Here, we …
Read PDF<h4>Background</h4>Long non-coding RNAs (lncRNAs) play pivotal regulatory roles in mammalian male gametogenesis. Advances in high-throughput technologies have demonstrated that lncRNAs orchestrate robust, flexible, and context-specific gene regulatory networks through dynamic interactions with proteins, DNA, and …
Read PDFDNA methylation modifies nucleotides, regulating gene expression without sequence change. The effects of DNA methylation within blood cell lineages on the development and function of endomitotic high DNA copy megakaryocytes (MKs) to anucleate platelets remain …
Read PDFEndogenous viral elements inserted in host genomes are often regarded as inert relics of past infections. Whether they can retain infective potential and contribute to active viral cycles has remained largely unresolved. Here we demonstrate …
Read PDFAnnotations of genomic features are cornerstone data that support routine workflows in conventional omics analyses in <i>Pseudomonas putida</i> KT2440 and other organisms. The GenBank and the RefSeq versions of the annotated KT2440 genome are two …
Read PDFThe integration of environmental cues into cellular programs is crucial for cell function. Yet, how this integration is modulated due to cellular aging remains unclear. We propose that the 3D chromatin organization filters these signals …
Read PDFThe gynoecium, a highly specialized structure in flowering plants, ensures their high reproductive success through the control of different crucial steps spanning from ovule protection to fertilization and seed maturation and dispersion. Multiple bpc mutants …
Read PDFGenome-wide association studies (GWASs) have linked numerous genetic loci active in vascular cells to coronary artery disease (CAD), implicating smooth muscle cells (SMCs) and SMC-derived mesenchymal cells as potential mediators. We combined CAD GWAS with …
Read PDFNF-κB signaling can be subdivided into canonical and noncanonical pathways, culminating in the transcriptional activity of RELA and RELB, respectively. However, the upstream signals that activate these transcription factors and their specific regulatory roles in …
Read PDFPancreatic ductal adenocarcinoma (PDAC) is a lethal cancer lacking effective drugs and therefore new treatment targets are needed. In this study, we define the role of homeobox protein B6 (HOXB6) and HOXB8 in controlling pancreatic …
Read PDFLTR retrotransposons are widespread genomic elements that significantly impact genome structure and function. In <i>Arabidopsis thaliana</i>, the EVD LTR retrotransposon encodes a GAG protein essential for retrotransposon particle assembly. Here, we present a comprehensive analysis …
Read PDFZebrafish larval tail regeneration can be broadly broken down into three phases: wound repair, initiation of regeneration and redevelopment of the tail. We and others have shown that activation of the Hedgehog and TGF-beta signalling …
Read PDFAicardi-Goutières syndrome (AGS) is a genetic type I interferon (IFN)-mediated disease characterized by neurological involvement with onset in utero or in childhood. Here, we analyze peripheral blood samples from patients bearing AGS-causing mutations in ADAR1, …
Read PDFThe epicardium is a fundamental regulator of cardiac development and regeneration, functioning to secrete essential growth factors and to produce epicardium-derived cells that contribute coronary mural cells and cardiac fibroblasts. The molecular mechanisms controlling epicardial …
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