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<b>Background:</b> Alternative promoter usage contributes to isoform diversity and gene regulation in mammals but remains difficult to study at scale. Cap Analysis of Gene Expression precisely maps transcription start sites, but its cost limits large-scale …
Read PDF<h4>Introduction</h4>Amyloid beta plaques and tau tangles are the primary hallmarks of Alzheimer's disease (AD). Recently, passive anti-Aβ immunotherapy for AD has markedly advanced, as supported by evidence from AD animal models and clinical trials. Whereas …
Read PDFEpigenetic regulation is a key determinant of adipocyte fate, driving the differentiation toward white or thermogenic beige phenotypes in response to environmental cues. To dissect the mechanisms orchestrating this plasticity in human adipocytes, we conducted …
Read PDFGene expression is regulated through a complex interplay between transcriptional and post-transcriptional mechanisms, yet their relative contributions and relationships remain incompletely understood. In this study, we propose normalized metrics to quantify regulatory density at each …
Read PDFDysregulation of RNA binding proteins (RBPs) is a hallmark in cancerous cells. In acute myeloid leukaemia (AML) RBPs are key regulators of tumour proliferation. While classical RBPs have defined RNA binding domains, RNA recognition and …
Read PDFNeurofibromatosis Type 1 (NF1) predisposes to peripheral nerve tumor development. The progression from a benign plexiform neurofibroma (PNF) towards a deadly malignant peripheral nerve sheath tumor (MPNST) is not completely understood but commonly involves the …
Read PDFTraumatic brain injury (TBI) causes progressive nervous tissue degeneration long after the initial injury due to secondary neuroinflammatory reactions. G protein-coupled dopamine D1-like receptors, which elevate intracellular cAMP levels, have been shown to mediate the …
Read PDFPhosphate deficiency reduces nodule formation in various legumes, which hinders nitrogen fixation and crop yield. We previously showed that phosphate deficiency reduces nodule formation by activating the autoregulation of nodulation (AON) pathway. We also observed …
Read PDFChromatin looping by CTCF and cohesin is thought to be crucial for chromosome organization and gene transcription. Yet the precise relationships between CTCF, cohesin, and transcription in neurons are still poorly understood. To address this …
Read PDF<h4>Introduction</h4>Drought negatively affects production in wheat, an important crop worldwide. Some <i>Trichoderma</i> spp. are of interest for sustainable agriculture. Upon plant root colonization, some strains produce multifaceted benefits for its host, including defence priming against …
Read PDFSpatial transcriptomics is an emerging technology that can analyze gene expression profiles of tissues while preserving spatial location information. To restore cell type proportions from mixed gene expression data, here we present DANST, a deconvolution …
Read PDFCellular RNA folds into complex helical structures that are attractive targets for controlling biological activity and treating diseases using RNA-binding ligands. Peptide nucleic acid (PNA) is a neutral DNA analog uniquely suited for triple-helical recognition …
Read PDFEmerging tolerance of <i>Schistosoma mansoni</i> to praziquantel, the only drug available for schistosomiasis treatment, highlights the need for new therapeutic targets. Snake venoms contain pharmacologically active proteins and peptides that can decrease the viability of …
Read PDF<b>Background</b><b>/Objectives</b>: Pest management strategies rely on insecticides such as deltamethrin (DM), a commonly applied type II pyrethroid. As a natural component of food-associated microflora, <i>Saccharomyces cerevisiae</i> inevitably encounters DM residues in crops used for fermentation …
Read PDF<h4>Introduction</h4><i>Xylella fastidiosa</i> is a phytopathogenic bacterium of worldwide importance causing detrimental diseases in several crops. Recent reports from European and Mediterranean countries raised great concerns and have given impetus to new studies investigating both the …
Read PDFStem lodging significantly reduces soybean yield stability, particularly under dense planting and intercropping systems. Stem breaking strength is a key component of lodging resistance, but its genetic basis remains incompletely understood. In this study, an …
Read PDFLipophagy is a form of selective autophagy that targets the lipid droplets for lysosomal decay and has been implicated in the onset and progression of metabolic dysfunction-associated steatotic liver disease (MASLD). Factors that augment lipophagy …
Read PDFLimiting the level of piglet losses before weaning is a growing demand from producers and society to improve the welfare and health of sows and piglets. In particular, perinatal mortality, which can be defined as …
Read PDF<h4>Background</h4>Hepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF) is characterized by intense systemic inflammation and immune dysregulation, with monocytes playing a central role in its progression. Patients with HBV-ACLF typically receive comprehensive treatment including artificial liver …
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