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<h4>Background</h4>Serrated neoplasia arises from serrated precursor lesions. Hyperplastic polyps commonly activate MAPK signalling, initiated by BRAF or KRAS mutation, but premalignant KRAS-mutant sessile serrated lesions are rare. Here, we model Kras- and Braf-mutant neoplasia in …
Read PDFPeritoneal dialysis (PD) is limited by insufficient phosphate removal, leading to adverse cardiovascular outcomes in patients with chronic kidney disease. To advance the understanding of the molecular mechanisms of peritoneal phosphate transport, RNAseq data of …
Read PDFHIV transcription is amplified by the viral transactivator Tat, yet two quantitative issues remain unresolved in chromatin: the extent to which host machinery sustains transcription in the absence of Tat, and why Tat's widespread chromatin …
Read PDFAlthough safflower (Carthamus tinctorius L.) is a momentous medicinal and industrial crop with intrinsic stress tolerance, molecular mechanism response to drought stress at the transcriptome level has been rarely scrutinized. Here, comprehensive transcriptome analysis was …
Read PDFDigestive cancers exhibit high heterogeneity and poor prognosis, yet whether their tumor microenvironments share conserved stromal-immune interactions remains unclear. Here, we performed an integrative multi-omics analysis across seven digestive cancer types and identified a conserved …
Read PDF<h4>Background</h4>Identifying safe and broad-spectrum antiviral and anti-inflammatory agents remains an urgent need in infectious and inflammatory diseases. Here, we demonstrated that MNS (NSC170724), a small-molecule nitrovinyl benzodioxole, enhanced antiviral defense while limiting excessive inflammation.<h4>Methods</h4>The antiviral …
Read PDFSingle-cell RNA sequencing inadequately predicts protein abundance, particularly for intracellular cytokines. We developed CIPHER-seq (Cytokine Intracellular Protein High-throughput Expression with RNA-sequencing), enabling simultaneous quantification of intracellular proteins and transcriptomes. This system provides five layers of …
Read PDFComparing organ-specific gene regulatory networks (GRNs) across large evolutionary distances remains a major challenge, particularly when the species under study differ in data resolution. This applies to the GRN controlling compound eye development in insects, …
Read PDFIn the whole laying cycle, the late laying phase is the longest segment, and it directly determines total egg production and influences the timing of culling. To investigate the mechanisms underlying the decline in egg-laying …
Read PDFThe antitumoral activity of monoamine receptor ligands appears to be important as a potential approach to cancer medication. In the present study, we evaluated the effects of trace amine compounds, including octopamine, tyramine, 3-methoxytyramine, and …
Read PDFPea aphids can develop alternative morphs when exposed to stressful conditions, showing differences between genotypes in their stress responses. Although several biological pathways regulating alternative morph production have been investigated, the role of epigenetic mechanisms …
Read PDFRegulatory circuits driving regional cell fate specification and lineage restriction decisions are not fully understood. The molecular mechanisms by which Hedgehog signaling controls lineage segregation in the posterior foregut remain unclear. Here, we employed bulk …
Read PDFDorsal root ganglion (DRG) neurons have a wide range of functions, including touch, pain and itch. These neurons have recently emerged as promising targets for non-invasive focused ultrasound (FUS) neuromodulation. However, our understanding of the …
Read PDFThe human genome is partitioned into functional compartments that replicate at specific times during S-phase. This temporal program, referred to as replication timing (RT), is coregulated with the 3D genome organization, is cell type-specific, and …
Read PDFThis study aimed to clarify the role Transforming Growth Factor Beta Induced (TGFBI) protein plays in corneal epithelial homeostasis by using RNA interference and to explore the possibility of gene therapy as a treatment modality …
Read PDFThyroid hormones (THs) regulate metabolism, proliferation, and genomic stability. Clinical studies have linked levothyroxine therapy with higher Oncotype DX Recurrence Scores in breast cancer (BC), suggesting a potential effect of thyroid hormone signaling on genomic …
Read PDFBreast cancer is the leading cause of death among women globally. Several genes have been found to be transcriptionally dysregulated in cancer, according to recent studies. TATA-box binding protein (TBP) and its two paralogs, TBPL1 …
Read PDF<h4>Background</h4>Cachexia is defined by chronic loss of fat and muscle, is a frequent complication of pancreatic ductal adenocarcinoma (PDAC) and negatively impacts patient outcomes. Nutritional supplementation cannot fully reverse tissue wasting, and the mechanisms underlying …
Read PDFImmunological mechanisms regulating HIV rebound after antiretroviral therapy (ART) interruption remain unclear. We examined relationships between host factors, HIV reservoir, and HIV time-to-rebound after analytical treatment interruption (ATI) by characterizing pre-ATI peripheral blood mononuclear cells …
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