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Flavescence dorée (FD), caused by FD phytoplasma (FDp) and transmitted by the leafhopper Scaphoideus titanus, is a quarantine disease that seriously threatens viticulture across Europe. Research on resistance or tolerance to FDp in grapevine is …
Read PDFPrimary cilia are increasingly recognized as regulators of cellular signaling and plasticity. Here, we examined their distribution and potential relevance in neuroendocrine (NE) prostate cancer. While typically absent in localized hormone-sensitive prostate tumor cells, we …
Read PDFEwing sarcoma is the second most common bone cancer in children and young adults. In 85% of patients, a translocation between chromosomes 11 and 22 results in a potent fusion oncoprotein, EWSR1::FLI1. EWSR1::FLI1 is the …
Read PDF<b>Background/Objectives:</b> Puerto Rican Hispanic/Latino (PR H/L) men experience a heightened incidence and mortality rate of aggressive forms of prostate cancer. The underlying causes of this increased disease burden likely include a complex interplay of socio-economic …
Read PDFA large fraction of newly transcribed RNA is degraded in the nucleus, but nuclear mRNA degradation pathways remain largely understudied. The yeast nuclear endoribonuclease Rnt1 has a well-characterized role in the maturation of many ncRNA …
Read PDFThe therapeutic potential of chimeric antigen receptor (CAR) T-cell therapy in treating solid tumors is highly recognized, yet the complex and immunosuppressive nature of the tumor microenvironment, poor accessibility, and the instability of target antigens …
Read PDFDUX4 initiates the first wave of zygotic genome activation (ZGA) in the human embryo, and its misexpression in skeletal muscle causes facioscapulohumeral muscular dystrophy (FSHD). However, other factors that help regulate ZGA-like transcription in human …
Read PDFMacrolide, lincosamide, and streptogramin (MLS) antibiotics are structurally distinct molecules that inhibit protein synthesis by binding overlapping sites within the 23S rRNA of bacterial ribosomes. The clinical utility of MLS antibiotics has diminished due to …
Read PDFCellular communication network (CCN) proteins are key matricellular regulators of cartilage development, yet their species-specific roles and network-level context remain unclear. This study integrated bulk RNA sequencing from chicken and mouse embryonic limb bud micromass …
Read PDF<h4>Objective</h4>Atherosclerosis remains a leading cause of global morbidity and mortality despite cholesterol-lowering drugs and risk factor management. In mice, the absence of coagulation factor XI (FXI) on an apolipoprotein E (apoE)<sup>-/-</sup> genetic background has been …
Read PDFTaro (Colocasia esculenta), a crop native to Southeast Asia, is classified under the genus Colocasia of the family Araceae. Here, the taro genome was assembled to the chromosome level, yielding a 2,336.63 Mb assembly with …
Read PDF<i>Fusarium</i> wilt, caused by <i>Fusarium oxysporum f.</i> sp. <i>vasinfectum 7</i> (FOV7), poses a major threat to the production of elite Sea Island cotton (<i>Gossypium barbadense</i>). To uncover the molecular basis of defense FOV7 in cotton, …
Read PDFGenerating condition-specific metabolic models by mapping gene expression data to genome-scale metabolic models (GEMs) is a routine approach to elucidate disease mechanisms from a metabolic perspective. On the other hand, integrating variants that perturb enzyme …
Read PDFEndocrine cells are dedicated to the production and processing of hormones, from peptides to small molecules, to regulate key physiological processes, including glucose homeostasis and metabolism. Because of this relatively high productivity, endocrine cells must …
Read PDFAutophagy is an essential cellular process which functions to maintain homeostasis in response to stressors such as starvation or infection. Here, we report that a subset of autophagy factors including ATG-3 play an antiviral role …
Read PDFCucumber (<i>Cucumis sativus</i> L.) is a globally significant vegetable crop, and its fruit quality remains a major focus of research. The hollow-heart trait, characterized by internal cracks or cavities, severely compromises both the commercial value …
Read PDF<h4>Background</h4>The emergence of flaviviruses and other arboviruses in novel geographic locations, arthropod vectors, and vertebrate amplification hosts complicates control and eradication efforts. Many flaviviruses continue to impact global health, including Zika virus (ZIKV) which has …
Read PDFSmall ruminants (sheep and goats) are one of the few mammals in which an exogenous retrovirus (XRV) and closely related endogenous retroviral (ERV) elements coexist within the same host genome. The betaretroviruses Jaagsiekte sheep retrovirus …
Read PDFPorcine epidemic diarrhea virus (PEDV) infection leads to serious intestinal disease in piglets, often leading to high mortality rates and substantial economic losses. Understanding host-PEDV interactions is crucial for PEDV therapeutic strategies. N<sup>6</sup>-methyladenosine (m<sup>6</sup>A) methylation …
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