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Fertilization ensures the flow of information from the parent to the progeny via fusion of male and female gametes orchestrated by a cascade of events guided by parental noncoding RNA (ncRNA) molecules. These parental ncRNAs …
Read PDF<h4>Background and objectives</h4>Oligodendrocytes (OLs) and their myelin-forming processes are lost during the disease course of multiple sclerosis (MS), targeted by infiltrating leukocytes and their effector cytokines. Myelin repair is considered to be dependent on recruitment …
Read PDF<h4>Background</h4>Lung cancer is the leading cause of cancer-related death in the world. Blimp-1 is a transcriptional repressor that, by interacting with other transcription factors in lymphocytes, regulates their cellular fate.<h4>Objective</h4>In this study, we focused on …
Read PDFMissing gene expression values are a common issue in RNAseq-based analyses of gene expression. However, an analysis of genetic and environmental factors contributing to data missingness in RNAseq-based assessment of gene expression has never been …
Read PDF<i>Mycobacterium abscessus</i> is a major human pathogen, mostly infecting people with pre-existing lung conditions, such as cystic fibrosis. The production of glycopeptidolipids (GPL) is a major determinant of virulence of this bacterium, with clinical isolates …
Read PDF<h4>Abstract</h4>Multiple myeloma (MM) is a plasma cell neoplasm that depends on the bone marrow (BM) microenvironment; however, the underlying mechanisms of epigenetic contribution to the pathogenesis of MM are incompletely understood. Here, we delineate epigenetically …
Read PDFDual RNA-seq enables simultaneous transcriptome profiling of interacting organisms, yet accurate read assignment remains challenging, particularly in fungal cocultures where phylogenetic proximity and high percentages of homologous sequences can be shared. Here, we evaluate two …
Read PDF<h4>Aim</h4>Cardiovascular diseases display strong sex differences. Angiotensin II (AngII) is implicated in this process. The ubiquitously expressed enzymatic beta subunit of calcineurin (PPP3CB), a serine/threonine phosphatase, can mediate pathological effects of AngII in the heart. …
Read PDFIn Saccharomyces cerevisiae, glucose depletion induces metabolic reprogramming through widespread transcriptional and translational reorganization. We report that initial, very rapid translational silencing is driven by a specialized metabolic mechanism. Following glucose withdrawal, intracellular NTP levels …
Read PDFYEATS2 is a chromatin-associated factor that regulates dopaminergic (DAergic) synaptic integrity, although its mechanism of action remains unclear. Here, we profiled head transcriptomic changes following neuron-specific <i>YEATS2</i> knockdown in <i>Drosophila</i>. This analysis revealed coordinated downregulation …
Read PDF<h4>Objective</h4>We investigated the role of GLI3, a transcription factor highly expressed in the pathogenic THY1<sup>+</sup>CD34<sup>-</sup> sublining subset of rheumatoid arthritis synovial fibroblasts (RASFs), in regulating their pathogenic behavior.<h4>Methods</h4>GLI3 protein levels were quantified in freshly isolated …
Read PDFAsthma poses a significant public health burden. Despite identifying more than a hundred genetic risk loci in genome-wide association studies (GWAS), the underlying functional mechanisms remain poorly understood. Studying omics, especially microRNAs (miRNAs), is a …
Read PDFAging alters cardiac resilience to anesthetic and surgical stress, yet the molecular basis for these effects remain poorly understood. To define age-dependent transcriptional responses, we profiled cardiac gene expression across young adult (3 m), late …
Read PDFChemotherapy-induced cognitive impairments (CICI), colloquially known as "chemobrain," represents a profound and debilitating side effect experienced by a significant number of cancer survivors, impacting their memory, multitasking, and quality of life. This review critically evaluates …
Read PDFAllele-specific expression (ASE) of somatic mutations can be caused by <i>cis</i>-activation of the mutant allele or silencing of the wild-type allele and has been investigated by examining the enrichment of mutant allele in RNA relative …
Read PDFAllergic asthma is driven by type 2 immune responses, including type 2 innate lymphoid cells (ILC2s). Although ILC2s are activated by the tissue alarmins interleukin (IL)-33 and IL-25, these signals do not intrinsically enforce type …
Read PDFEsophageal squamous cell carcinoma (ESCC) remains a highly aggressive malignancy with dismal clinical outcomes and limited treatment options. NAD(P)H quinone oxidoreductase 1 (NQO1) is classically characterized as a cytosolic oxidoreductase that prevents the formation of …
Read PDF<h4>Background</h4>Papain-like cysteine protease (PLCP), a vital subgroup of peptidases, play crucial roles in various biological processes including plant growth, seed germination, anther development, and stress responses.<h4>Results</h4>In this study, 44 FvPLCP genes were identified through phylogenetic …
Read PDF<b>Background:</b> Fertility preservation aims to maintain reproductive potential in patients undergoing potentially gonadotoxic treatments, increasingly relying on centralized cryobanks requiring ovarian tissue transport. Ovarian tissue cryopreservation is a widely implemented, evidence-based procedure for young women …
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