Search the literature by keyword, topic, or author. Filter to articles with full text available.
10021 results
High-grade serous ovarian cancer (HGSC) accounts for more than 70% of ovarian cancer-related deaths, yet therapeutic progress remains stagnant. Among the four molecular subtypes reported for HGSC, the C5 subtype is distinguished by high proliferation …
Read PDFNoncoding RNAs play pivotal roles in tumorigenesis and cancer progression. Recent evidence has identified vault RNAs (vtRNAs) as critical regulators of cellular homeostasis. The human genome encodes four vtRNA paralogs, which are differentially expressed in …
Read PDFDiffuse intrinsic pontine glioma (DIPG) is the pediatric tumor with the worst prognosis. BIOMEDE was a randomized phase 2 trial comparing the efficacy in terms of overall survival (OS) (primary endpoint) of epidermal growth factor …
Read PDFStudying how microenvironmental cues influence metabolic reprogramming can uncover mechanisms driving tumor progression. Using an in vitro model with proliferative stimuli of the in vivo lymph node niche (LN)-including interleukin-21 (IL-21)-we examined metabolic rewiring in …
Read PDF<h4>Background</h4>Endometriosis is a gynecological disorder that affects 190 million reproductive age women worldwide. Laparoscopic surgery is considered the gold standard to diagnose the disease, creating a barrier to diagnosis and leading to long delays in …
Read PDFOver the past few decades, it has become increasingly clear that small RNAs (sRNAs) play important regulatory roles in bacteria. These RNA species often work in concert with RNA chaperones such as Hfq that facilitate …
Read PDFStudying microbial biodiversity offers enormous potential for improving the valorisation of plant biomass, particularly in conversion processes. Microorganisms, such as bacteria, fungi, yeasts and algae, play an essential role in degrading plant biomass and can …
Read PDFHow robustness and plasticity-mechanisms that restrain or promote variation- interact to generate faithful developmental outcomes remains unclear. <i>Caenorhabditis elegans</i> development, where different environmental and genetic stimuli each can induce larvae to switch from continuous growth …
Read PDFCancer subtype classification is critical for precision therapy, and there is a growing trend to augment histopathology testing with omics-based machine learning classifiers. However, analytical challenges remain in pediatric cancer regarding the scope and precision …
Read PDF<h4>Introduction</h4>Sepsis is a life-threatening organ dysfunction syndrome with persistently high global mortality, driven by dysregulated host immune response. Existing single-target therapies fail to simultaneously address hyperinflammation and impaired tissue repair, leading to limited clinical efficacy …
Read PDFHistone deacetylase inhibitors (HDIs) are approved for treating hematologic cancers and are currently being evaluated in hundreds of clinical trials for various cancers and other diseases, although their mechanisms of action remain poorly understood. Here, …
Read PDFBACKGROUND: Pancreatic ductal adenocarcinoma (PDAC) is an aggressive solid tumor with poor prognosis. Existing prognostication systems rely on clinical staging, but systems of tumor classification through molecular signatures and the association between cancer-associated fibroblast (CAF) …
Read PDFIntramuscular fat (IMF) is a pivotal determinant of meat quality in yaks (<i>Bos grunniens</i>). While nutritional factors are well-documented, the epigenetic landscape, particularly the transcriptional architecture governed by super-enhancers (SEs), remains largely unexplored in the …
Read PDFRNA regulation plays a central role in neurodevelopment by coordinating neuronal differentiation, migration, and circuit formation. The CUGBP Elav-like family member 2 (CELF2) is an RNA-binding protein with established roles in alternative splicing and mRNA …
Read PDFPeripheral blood mononuclear cells (PBMCs) represent a critical component of the immune system, orchestrating both cellular and humoral responses while maintaining immunological homeostasis. This study investigates the PBMC immune response to Pasteurella multocida (P. multocida) …
Read PDF<h4>Background</h4>Many patients with cancer benefit little from immune checkpoint blockade (ICB), a major obstacle to immunotherapy for decades. Finding alternative immune checkpoints that control CD8<sup>+</sup> T-cell exhaustion is urgent if we are to improve the …
Read PDFIntervertebral disc degeneration (IVDD) is increasingly recognized as a systemic collapse of the epigenetic regulatory network, driven by cellular senescence and environmental stressors. The present review provides an overview of the epigenetic regulatory mechanisms governing …
Read PDFIntrinsic and acquired resistance to poly(ADP-ribose) polymerase (PARP) inhibitors (PARPi) remains a major barrier in treating homologous recombination (HR) repair-deficient tumors, including those with germline or somatic <i>BRCA1/2</i> mutations. Although PARPi are FDA approved for …
Read PDFOur recent study using <i>in silico</i> data mining identified novel culterviruses (family: <i>Bornaviridae</i>) in fish, including a variant of Wuhan sharpbelly bornavirus (WhSBV) in grass carp kidney and liver cell lines. Here, metagenomic sequencing of …
Read PDF