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Brain metastasis (BM) remains largely incurable. Cancer-associated fibroblasts (CAFs) can either support or inhibit tumor growth in the tumor microenvironment (TME), yet their role in BM is not well described. In this study we define …
Read PDFThe inflammation-intestinal metaplasia (IM)-carcinoma cascade has been proposed as a framework for gastric cancer (GC) development, yet the cell-level heterogeneity and microenvironmental remodeling underlying this progression remain poorly characterized. Here, we constructed a single-cell transcriptomic …
Read PDF<h4>Abstract</h4>Immunotherapy represents a promising strategy to improve outcomes in pediatric leukemia; however, its efficacy remains considerably lower in acute myeloid leukemia (AML) compared with B-cell acute lymphoblastic leukemia (B-ALL). To characterize T-cell subsets in AML …
Read PDF<h4>Background</h4>The intratumoral heterogeneity and immunosuppressive microenvironment of hepatocellular carcinoma (HCC) significantly limit therapeutic efficacy. Although efferocytosis is fundamental for tissue homeostasis, its impact on the spatial architecture of the tumor microenvironment (TME) and patient prognosis …
Read PDF<h4>Background & aims</h4>The liver is a vital organ composed of parenchymal, non-parenchymal, and immune cell populations. Single-cell sequencing approaches now provide the opportunity to understand how sex and age influence gene expression and cellular function …
Read PDFGallbladder inflammation comprises distinct pathological entities, including acute, neutrophil-dominated injury and chronic, fibrotic remodeling. This study aimed to define the cellular and structural programs that characterize these two inflammatory states and link epithelial, immune, and …
Read PDFEpilepsy is a common neurological disease that affects a wide range of people and seriously impairs patients' quality of life and social adaptability. Neuroinflammation plays an important role in the pathogenesis of epilepsy. Glial cells, …
Read PDFBACKGROUND: This study investigates the epigenetic-metabolic interplay in endometrial cancer (EC) through integrated single-cell and bulk multi-omics analyses, aiming to identify prognostic biomarkers and elucidate mechanisms driving metabolic reprogramming. METHODS: Single-cell RNA sequencing (scRNA-seq) data …
Read PDFGlioblastoma (GBM) is characterized by hypoxia-driven metabolic adaptation and profound therapeutic resistance. Ferroptosis, an iron-dependent lipid peroxidation-related cell death process, has emerged as a potential vulnerability; however, its relationship with hypoxia signaling remains incompletely defined. …
Read PDF<h4>Background</h4>The role of extrachromosomal DNA (ecDNA)-related genes in osteosarcoma remains largely unexplored. The aim of this study is to investigate the association between ecDNA-related genes and prognosis and tumor microenvironment (TME) in osteosarcoma.<h4>Methods</h4>Differential gene expression …
Read PDFSingle-cell RNA sequencing (scRNA-seq) provides a comprehensive understanding of cellular complexity; however, its requirement for fresh or frozen samples limits its flexibility. To overcome this limitation to effectively leverage clinical samples, Chromium Fixed RNA Profiling …
Read PDF<h4>Background</h4>Ischemic stroke results in significant morbidity and mortality. By examining gene expression of cells comprising stroke clots, we aim to gain valuable insights into the underlying mechanisms of this disease and identify potential biomarkers of …
Read PDFInflammation progressively increases with age, resulting in a broad remodeling of the CD8⁺ T cell compartment. Recent advances in single-cell RNA sequencing (scRNA-seq) have revealed a transcriptional heterogeneity within the CD8⁺ T cell subsets, challenging …
Read PDF<h4>Purpose</h4>This study aims to identify pathogenic retinitis pigmentosa G<i>TPase regulator</i> (<i>RPGR</i>) mutations in a Chinese pedigree with X-linked retinitis pigmentosa (XLRP) and elucidate the cellular and molecular mechanisms underlying <i>RPGR</i>-associated photoreceptor degeneration through the integrated …
Read PDFColorectal cancer (CRC) is one of the most common malignancies worldwide and remains a major cause of cancer-related mortality. Increasing evidence suggests that aberrant RNA metabolism contributes to tumour initiation, progression and therapeutic resistance. In …
Read PDFLymph node metastasis (LNM) represents a distinctive stage in cancer progression, exerting a profound impact on patient prognosis. Accumulating studies have unveiled that tumor-draining lymph nodes (TDLNs) play a pivotal role in immunotherapy, functioning as …
Read PDFNeurons in the lateral geniculate nucleus (LGN) provide a pivotal role in the visual system by modulating and relaying signals from the retina to the visual cortex. Although the primate LGN, with its distinct divisions …
Read PDFHidradenitis suppurativa (HS) is a chronic inflammatory skin disease with limited treatment options and frequent drug resistance. Novel therapeutic targets are urgently needed. We performed a druggable genome-wide Mendelian randomization (MR) analysis using blood cis-expression …
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