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Background: Papillary thyroid cancer is a common head and neck malignancy with a globally rising incidence. While most patients attain favorable prognosis following standard treatment, a subset develops recurrence and metastasis—two key factors that compromise …
Read PDFUnderage drinking has become a global public health concern. One of the major causes of underage drinking is stress. The orexin system has been reported to be involved in both alcohol addiction and stress. However, …
Read PDF<h4>Summary</h4>The "Integrative Metabolic-Flux Platform for Analysis, Contextualization, and Targeting" (IMPACT) is a comprehensive, fully modular platform designed for both targeted and untargeted metabolomics analysis in stable-isotope labeling experiments. It facilitates the accurate calculation of mass …
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Read PDF<h4>Motivation</h4>Antimicrobial resistance surveillance in ESKAPEE pathogens (<i>Enterococcus faecium</i>, <i>Staphylococcus aureus</i>, <i>Klebsiella pneumoniae</i>, <i>Acinetobacter baumannii</i>, <i>Pseudomonas aeruginosa</i>, <i>Enterobacter</i> spp., and <i>Escherichia coli</i>) requires reproducible, portable whole-genome analysis that public health laboratories including those operating under data-sovereignty …
Read PDF<h4>Motivation</h4>The exponential growth of non-coding RNA research-with over 230 000 papers published since 2000-has created an urgent knowledge management crisis in molecular biology. Despite their crucial regulatory roles, microRNAs (miRNAs) face a significant curation bottleneck, …
Read PDF<h4>Summary</h4>High-fidelity genome assemblies provide unprecedented opportunities to decipher mechanisms of molecular evolution and phenotype landscapes. Here, we present PseudoChecker2, a command-line version of the web-tool PseudoChecker with expanded functions. It identifies gene loss via drastic …
Read PDF<h4>Motivation</h4>With nearly 266,500 viruses cataloged currently at NCBI and increasing by the day, identifying the diseases they cause, and the affected hosts remains challenging. Hence the motivation for undertaking this study.<h4>Results</h4>Utilizing the AI-powered tools, we …
Read PDF<h4>Introduction and aims</h4>Odontogenic differentiation of human dental pulp stem cells (hDPSCs) is critical for pulp repair. This study aims to characterise the secretory peptidome of human dental pulp stem cells (hDPSCs) during odontogenic differentiation, thereby …
Read PDF<h4>Introduction</h4>Gallbladder adenosquamous carcinoma (GBASC) is an uncommon, highly aggressive neoplasm characterized by the coexistence of both glandular and squamous cells. Representing fewer than 5% of gallbladder malignancies, GBASC demonstrates a more aggressive behavior and has …
Read PDFQuantitative trait locus (QTL) mapping is a powerful approach to uncover the genetic architecture of complex traits. Traditional biparental populations, though widely used, offer limited genetic diversity and resolution, making them less effective for robust …
Read PDF<h4>Objectives</h4>This study investigated the association between miR-146a-3p rs2910164 polymorphism and peri-implantitis (PI) susceptibility in the Han Chinese population, as well as the potential mechanisms underlying PI progression.<h4>Material and methods</h4>183 PI patients and 219 individuals with …
Read PDF<h4>Motivation</h4>Operons are fundamental units of gene regulation in bacteria and can provide valuable insights into genome organization, co-expression, and functional relationships between genes. Computational prediction of operons can support downstream analyses such as pathway reconstruction, …
Read PDFWe devised a quantitative scoring function to assess the cumulative effects of somatic nonsynonymous single-nucleotide variants (SNVs) on protein-coding genes in patients with ovarian cancer (OvCa) and thyroid cancer (ThCa). The goal is to find …
Read PDF<h4>Motivation</h4>Biomedical Entity Linking (BEL) maps mentions in biomedical text to standardized identifiers, enabling structured data integration and downstream knowledge discovery. However, current BEL systems remain fundamentally constrained by the recall of the initial candidate pool, …
Read PDF[This corrects the article DOI: 10.3389/fimmu.2025.1576042.].
Read PDFThe present study aimed to investigate the functional role and molecular mechanisms of long intergenic non‑protein coding RNA 1117 (LINC01117) in lung adenocarcinoma (LUAD). Bioinformatics analysis was performed to assess the expression level and prognostic …
Read PDF<h4>Motivation</h4>Citation is central to scholarly communication, enabling researchers to navigate rapidly expanding literature and identify relevant prior work. Yet the 'reasoning' behind why a particular paper is cited is often implicit or opaque. Although academic …
Read PDF<h4>Objective</h4>This study investigates the role of the protocadherin-1 (PCDH1) gene in pancreatic cancer metastasis, focusing on its influence on the epithelial-mesenchymal transition (EMT) process and the NF-κB signaling pathway.<h4>Methods</h4>Clinical specimens from pancreatic cancer patients were …
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