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<h4>Background/aim</h4>Chemotherapy with gemcitabine and cisplatin remains the cornerstone of treatment for advanced urothelial carcinoma (UC), yet response rates vary significantly among patients. Predicting treatment response is crucial to avoid unnecessary toxicity and optimize therapeutic strategies. …
Read PDF<i>Lactococcus petauri</i> is an emerging fish pathogen linked to septicemia. We report draft genome sequences of two <i>L. petauri</i> isolates from independent lactococcosis outbreaks in Mexican fish farms. This study confirms <i>L. petauri</i> presence in …
Read PDFSepticemia remains a major cause of death in intensive care units and its treatment is increasingly challenged by multidrug-resistant pathogens. This study investigated bloodstream infections in 89 ICU patients at a tertiary hospital in Sikkim …
Read PDF<h4>Background</h4>In chronic kidney disease (CKD), there is evidence of loss of function and fibrosis in the progression of tubular epithelial cells; however, the cellular heterogeneity and underlying molecular mechanisms are not well defined. Knowledge of …
Read PDFBeetleAtlas is an online resource for tissue- and stage-specific transcriptomics in the red flour beetle, Tribolium castaneum. On updating from the original Tcas5.2 genome assembly to the more recent improved icTriCast1.1 genome assembly it became …
Read PDFWe present a contemporary high-quality, complete <i>de novo</i> assembly of <i>Wolbachia pipientis</i> (<i>w</i>Ri Merrill 23, OZ411647), an alphaproteobacterial endosymbiont of <i>Drosophila simulans (D. simulans)</i>. This assembly was generated using long-read sequencing of <i>w</i>Ri-infected <i>D. simulans</i> …
Read PDF<h4>Background</h4>The integration of genomics into Australian health services offers significant benefits for the diagnosis and delivery of targeted treatments, but its success relies on a workforce equipped to deliver genomic-informed care. Nurses and midwives, Australia's …
Read PDFSocial insects are key models for phenotypic plasticity, as queens and workers show striking differences in behaviour and lifespan despite sharing the same genome. Neuropeptides are central regulators of behavioural plasticity, and caste-specific ageing is …
Read PDF<h4>Objective</h4>The involvement of methyltransferase-like 3 (METTL3, an m6A methyltransferase) and the PI3K/AKT pathway in tumor progression and immune regulation remains poorly understood. This study investigates whether METTL3 influences the immune microenvironment of renal cell carcinoma …
Read PDFBACKGROUND: Spermatozoa are produced in the testis and acquire motility and fertilizing capacity during post-testicular maturation in the epididymis, a highly region-specific process. How gene loss reshapes region-specific transcriptional programs along the testis–epididymis axis remains …
Read PDFInvestigating the genetic architecture of complex diseases is challenging due to the multifactorial interplay of genomic and environmental influences. Although GWAS have identified thousands of variants for multiple complex traits, conventional statistical approaches can be …
Read PDFThe Electronic Medical Records and Genomics (eMERGE) Network developed and implemented a genome-informed risk assessment (GIRA) to communicate genomic (polygenic risk scores [PRSs], integrated risk scores [IRSs], and monogenic results), clinical, and family history-based risk …
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Read PDFPropionic acidemia (PA) is a rare autosomal recessive metabolic disorder caused by functional deficiency of propionyl-CoA carboxylase, clinically characterized by life-threatening ketoacidosis, hyperammonemia, and multiorgan dysfunction. Due to its nonspecific clinical manifestations, PA is frequently …
Read PDFTo explore the allelopathic response mechanism of Elymus nutans to the extracts of Ligularia sagitta, seed germination tests combined with integrated transcriptome and metabolome analyses were performed to systematically investigate the effects of the extracts …
Read PDF<i>Chlamydia pecorum</i> is globally recognised as an important pathogen of both agricultural and conservation concerns, contributing to significant production losses in livestock and debilitating disease in koalas (<i>Phascolarctos cinereus</i>). This scoping review evaluates the current …
Read PDFEpigenetic features, such as histone modifications and higher-order genome organization, are fundamental determinants of cell-specific gene expression. However, while the HL-1 cell line is a widely utilized model for cardiac research, a comprehensive and integrated …
Read PDF<h4>Background</h4>Tuberculosis (TB) remains a major global health threat, causing approximately 1.5 million deaths each year. Despite progress in treatment, 15%-20% of patients still experience treatment failure or relapse, highlighting the urgent need for precise predictive …
Read PDF<i>Staphylococcus pseudintermedius</i> is an opportunistic bacterium previously associated with dogs but has recently been found in human infections, raising zoonotic concerns. Genomic characterization of human <i>S. pseudintermedius</i> isolates can provide preliminary information on antibiotic resistance, …
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