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Thiopurine medications are widely used for the treatment of acute lymphoblastic leukemia and inflammatory bowel disease. However, thiopurine-induced hemotoxicity occurs in up to 30% of patients, which causes substantial morbidity and limits therapeutic success. These …
Read PDF<h4>Background</h4>Phosphorus (P) utilization is a complex trait influenced by numerous genetic variants. The jejunum is the primary site of P absorption in poultry. Therefore, identifying the genetics that regulate transcription in jejunum may help uncover …
Read PDFBACKGROUND: Bifid nose with or without anorectal and renal anomalies (BNAR) is a rare autosomal recessive genetic congenital disorder characterized by bifid nose and renal agenesis, with or without anorectal malformations. Our research identified the …
Read PDFThe occurrence of myelodysplastic syndrome (MDS) in children is infrequently documented and most commonly manifests in the form of refractory cytopenia of childhood (RCC). The management of pediatric MDS remains controversial and involves primarily chemotherapy, …
Read PDFPassion fruit (Passiflora edulis) is a highly nutritious horticultural crop cultivated widely across tropical and subtropical regions. Despite decades of breeding efforts that have led to the release of a few high-yielding cultivars, on-farm productivity …
Read PDFBACKGROUND: Tumor heterogeneity poses a major challenge to elucidating the mechanisms underlying tumor progression and metastasis. However, the cellular heterogeneity of triple-negative breast cancer (TNBC) remains incompletely understood. METHODS: We performed an integrated analysis of …
Read PDFFunctional enrichment analysis (FEA) is an incredibly powerful way to summarise complex genomics data into information about the regulation of biological pathways including cellular metabolism, signalling and immune responses. About 10,000 scientific articles describe using …
Read PDFBACKGROUND: Accessory genome regions of plant pathogenic fungi, which are highly variable and consist of niche-adaptive genes, play a crucial role in shaping host-specific interactions but are notoriously difficult to assemble. Fusarium oxysporum causes some …
Read PDFProphages can constitute up to 30% of the accessory genome in <i>Salmonella</i> enterica, acting as major drivers of virulence evolution and antimicrobial resistance; however, their diversity and functional contribution in Ecuadorian poultry-associated lineages remain unexplored. …
Read PDFPalmitoylation, a critical post-translational modification mechanism, plays a pivotal role in hepatocellular carcinoma (HCC) tumorigenesis and progression. While multiple palmitoylated proteins have been reported to regulate HCC development, systematic characterization of palmitoylation-associated gene signatures and …
Read PDFAdvances in genomics have transformed histopathology, especially in oncology teaching. Histopathologists traditionally assess tissue morphology, but now integrate genomic data to enhance diagnostic accuracy and treatment precision. Students must grasp both disciplines and appreciate the …
Read PDFThis report presents the draft genome sequence of a lactic acid bacterium, <i>Limosilactobacillus fermentum</i> PJG11, isolated from wild yam, <i>Dioscorea luzonensis</i>, an endemic root crop in Ilocos Norte, Philippines. The discovered genomic characteristics of the …
Read PDFMicroorganisms represent the Earth's most abundant biomass and a vast reservoir of genetic diversity. However, traditional agar plate methods fail to recover the vast majority of these species, leaving a "microbial dark matter" that holds …
Read PDFUnderstanding how dispersal, life history, and environmental variability shape genetic connectivity in the open ocean remains a central challenge in evolutionary biology. Highly migratory marine predators like tunas have traditionally been considered genetically homogeneous across …
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