Correction: Advancing artificial intelligence ethics in health and genomics: lessons from a public survey in South Korea
[This corrects the article DOI: 10.3389/fgene.2025.1563544.].
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The UCSC Genome Browser database: 2026 update
Now in its 25th year of operation, the UCSC Genome Browser (https://genome.ucsc.edu) provides a central location for researchers around the world to display and compare annotations on assembled genomes. Highlighted updates include a positional heatmap …
Read PDFEvolutionary and functional constraints structure human gene research visibility
<h4>Background</h4>Biomedical research effort is distributed highly unevenly across human genes, with a small subset dominating the scientific literature while thousands remain sparsely studied. Whether this imbalance reflects intrinsic biological importance or historically reinforced research bias …
Read PDFEditorial: Antimicrobial resistance: tracking and tackling in the food chain
No abstract available.
Read PDFThe Missing Piece: Functional Telomerase Restored in the Beetle Model
The red flour beetle Tribolium castaneum yielded the first resolved telomerase reverse transcriptase structure but lacked a known telomerase RNA. We identify two telomerase RNA paralogs in Tribolium, confirm their expression, and reconstitute active telomerase …
Read PDFDecoding cellular communication networks and signaling pathways in bone, skeletal muscle, and bone-muscle crosstalk through spatial transcriptomics in a young male mouse
Bone and skeletal muscle are essential components of musculoskeletal system, enabling movement, load-bearing, and systemic homeostasis. These tissues communicate through dynamic bone-muscle crosstalk mediated by cytokines, growth factors, and extracellular-matrix (ECM) proteins. The spatial organization …
Read PDFPan-genomics of polyploid crops: from complexity to breeding
Improving crop productivity is essential to ensure global food security in the context of climate change and an increasing global population. Over the past few decades, sequencing has significantly expanded our ability to explore complex …
Read PDFNIA Genetics of Alzheimer's Disease Data Storage Site (NIAGADS): 2025 Update
No abstract available.
Read PDFDivergent genetic and phenotypic trajectories in China' s maize hybrids
Maize germplasm is fundamental for breeding progress, yet the genetic and phenotypic trajectories of China’s modern commercial hybrids are poorly characterized. Through whole-genome resequencing of the hybrids themselves—which directly represent commercially deployed varieties— and multi-trait …
Read PDFComplete genome sequence of <i>Cronobacter muytjensii</i> bacteriophage vB_Cmu_VP5
<i>Cronobacter muytjensii</i> is a gram-negative bacterium associated with public health concerns. Here, we report the characterization of cronophage vB_Cmu_VP5. Genome analysis indicates that vB_Cmu_VP5 is a member of the class Caudoviricetes. The genome contains 47 …
Read PDFComparison between a conventional tool and deep learning models for RNA velocity analysis of scRNA-Seq data
Single-cell RNA sequencing (scRNA-Seq) enables analysis of gene expression at single-cell resolution. RNA velocity analysis infers the temporal dynamics of transcriptional states from the relative abundances of spliced/unspliced mRNA quantified via scRNA-Seq. Classical RNA velocity …
Read PDFVision for Exposomics-Scale Investigation: A Heuristic for Exposure-Wide Association Studies (ExWAS)
Exposomics has the potential to revolutionize biomedical research. However, the transition from hypothesis-driven to discovery-driven research has created tension between expansive screening and the risk of false discoveries. To meet the rigorous expectations of funders, …
Read PDFPreparing healthcare providers to use polygenic risk scores: a qualitative study of learning needs and educational preferences
<h4>Objectives</h4>Polygenic risk scores are increasingly available to consumers to provide an estimate of the genetic contribution to health conditions. However, healthcare providers report limited knowledge and confidence using polygenic risk scores. Clinical implementation necessitates educational …
Read PDFVUStruct: A compute pipeline for high throughput and personalized structural biology
Effective diagnosis and treatment of rare genetic disorders requires the interpretation of a patient's genetic variants of unknown significance (VUSs). Today, clinical decision-making is primarily guided by gene-phenotype association databases and DNA-based scoring methods. Our …
Read PDFAssociation for Clinical Genomic Science (ACGS) guidelines for the classification of oncogenicity of somatic variants in cancer: recommendations by the UK somatic variant interpretation group (SVIG-UK)
Comprehensive genomic testing in routine cancer care pathways has created the need to interpret the consequences of somatic (acquired) genomic variants beyond the currently well-characterised driver variants in cancer gene hotspots. While several guidelines have …
Read PDFValidation of the HER2DX genomic test in first-line advanced HER2-positive breast cancer treated with trastuzumab, pertuzumab, and taxane
Trastuzumab, pertuzumab, and a taxane (THP) has been the standard first-line therapy for HER2+ advanced breast cancer for over a decade. With new regimens emerging, genomic tools like HER2DX may help identify patients who benefit …
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