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Phage genomes integrated within bacterial genomes, known as prophages, frequently encode proteins that provide defense against further phage infection. These proteins often function by altering the cell surface and preventing phages from attaching to their …
Read PDFGenome-wide off-target effect poses a safety risk for clinical use of adenine base editor (ABE), among which ABE8e is one of the most efficient. Genome-wide off-target analysis by two-cell embryo injection (GOTI) analysis showed that …
Read PDFRetinoblastoma (RB) is the most prevalent malignant tumor that originates within the eye in children, occurring at a frequency of around 1:20,000 to 1:15,000. RB typically occurs when both alleles of the retinoblastoma 1 (RB1) …
Read PDF<h4>Objective</h4>Ultrasound findings of fetal edema may provide early evidence of a genetic disorder. Our objective was to evaluate the frequency and diagnostic yield of sequencing in a selected population after a non-diagnostic microarray result for …
Read PDF<h4>Background</h4>Yogurt is reported to maintain the balance of gut microbiota and prevent disease, but the causal relationship remains unclear.<h4>Methods</h4>We selected data from UK Biobank and MiBioGen to perform Mendelian randomization analysis. MR Egger, inverse variance …
Read PDF<h4>Background</h4>Epigenetic medication, such as RNA 5-methylcytosine (m5C), is well-recognized as a key regulator in hepatic metabolism and immune responses. However, m5C regulatory mechanisms in NASH pathogenesis have not yet been clearly elucidated.<h4>Methods</h4>By utilizing three bulk …
Read PDFCirculating tumor DNA (ctDNA) has many potential applications in the management of cancer, including detection, monitoring, and treatment response assessment. This study evaluates pre-treatment ctDNA detection in a single-institution pan-cancer cohort using a highly sensitive …
Read PDFIn response to the triple crises of global resource depletion, escalating waste generation, and environmental pollution, microorganisms are increasingly transitioning from basic research to engineering applications, driven by their metabolic diversity, robust environmental adaptability, and …
Read PDFIn response to the emerging threat of insecticide resistance in malaria vectors, insecticides are being repurposed for vector control or developed de novo. The longevity of disease control programs will require stewardship of these tools, …
Read PDFColorectal cancer (CRC) remains a leading cause of cancer-related mortality worldwide, with tumor microenvironment (TME) heterogeneity playing a critical role in disease progression and therapeutic response. Immune escape (IE) mechanisms facilitate tumor evasion from host …
Read PDFNeurofibromatosis 1 (NF1) is one of the most common genetic diseases of the central nervous system. The nature of intracranial lesions that are associated with NF1 are yet to be fully defined. Arachnoid, velum interpositum, …
Read PDF<h4>Background</h4>Globally, subsistence-level societies are experiencing rapid urbanization and concomitant increases in cardiometabolic diseases. Generalized measures to quantify lifestyle transitions will facilitate the identification of the most potent drivers of changing health within and between populations, …
Read PDFBACKGROUND: Gene regulatory evolution is a well-known source of phenotypic diversity and adaptive evolution. Although cis-regulatory elements (CREs) play a vital role in gene expression evolution, the molecular evolution of CREs remains mostly unknown due …
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