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This study reports the draft genome sequence of <i>Enterobacter hormaechei</i> ML02, isolated from mangrove-associated rhizosphere soil in Bangladesh. The assembled genome is 4,874,798 base pairs in length, distributed across 80 contigs, with a GC content …
Read PDFTo elucidate the molecular mechanisms underlying grain size formation in barley, this study selected two distinct barley cultivars with significant differences in grain dimensions: the large-grained cultivar 'jianglinhuang' and the small-grained cultivar 'heiseyeqingke'. We conducted …
Read PDFThe ectomycorrhizal fungus <i>Laccaria bicolor</i> is a key symbiotic mutualist in forest ecosystems, where it enhances nutrient uptake and promotes the growth of host trees. Here, we present genome assemblies of 14 geographically distinct strains …
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Read PDFThe medicinal plant Coptis chinensis is highly susceptible to root rot caused predominantly by Fusarium spp., threatening yield and medicinal quality. Biological control agents (BCAs) from the genus Bacillus are promising, yet their host mechanisms …
Read PDFTumor hypoxia is biologically important in breast cancer, but its prognostic value may be distorted by intrinsic molecular subtype composition. This study evaluated whether hypoxia-related prognosis was subtype-dependent and whether hypoxia was associated with genome-wide …
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Read PDF<h4>Background</h4>Laryngeal cancer (LC) is a common malignant tumor. Telomere-related genes (T-RGs) play critical roles in cellular senescence and carcinogenesis, but their prognostic relevance in LC remains to be fully elucidated. Therefore, exploring the prognostic genes …
Read PDF<i>Bordetella petrii</i> is an environmentally versatile Gram-negative bacterium with hydrocarbon-degrading capabilities, yet its genetic and metabolic characteristics remain poorly characterized. This study investigated the genomic features of a PAH-degrading <i>Bordetella petrii</i> strain P003 isolated from …
Read PDFDespite the escalating biodiversity crisis, many species remain unknown to science and may even disappear unnoticed. This is particularly true for many island populations. We illustrate the problem of detecting overlooked species and its consequences …
Read PDF<i>Streptococcus pneumoniae</i> remains a major cause of morbidity and mortality worldwide, especially among children under 5 years of age. The introduction of pneumococcal conjugate vaccines (PCVs) has significantly reduced invasive pneumococcal disease globally. Ghana introduced …
Read PDFCancer research has undergone a fundamental transformation in recent decades due to the integration of artificial intelligence (AI) models into the study of tumor biology. However, tumor evolution, driven by genetic and phenotypic alterations leading …
Read PDFDigitalis purpurea (foxglove) is a widely distributed ornamental plant. Here, we present a long read sequencing-based genome sequence of a magenta flowering D. purpurea plant and a corresponding prediction of gene models. The high assembly …
Read PDFPantoea agglomerans is a Gram-negative bacterium increasingly recognised as an opportunistic pathogen, yet the molecular basis underpinning its host-interaction capacity remains poorly understood. Here, we report the whole-genome sequencing and integrative characterisation of P. agglomerans …
Read PDFBACKGROUND: Imported malaria cases, driven by human migration and travel, pose a significant challenge to malaria elimination efforts. Genomic approaches have become essential for distinguishing between local transmission and imported infections. The state of Sarawak, …
Read PDFBACKGROUND: Dopa-responsive Dystonia (DRD) due to GTP cyclohydrolase 1 (GTPCH1) deficiency is a neurogenetic disorder caused by pathogenic GCH1 variants. Tetrahydrobiopterin (BH4) deficiency impairs dopamine synthesis in the basal ganglia, leading to childhood-onset dystonia with …
Read PDFModern biomedical genomics has principally centered on disease, leveraging genomic insights to identify disease-associated genotypes. While valuable, this approach is overly reliant on a positivist, disease-centric perspective that often goes hand-in-hand with patterns like deficit …
Read PDF<h4>Background</h4>Luminal B-like breast cancer (LBBC) constitutes approximately 40% of breast cancer cases and carries a higher risk of recurrence and poorer prognosis than luminal A-like disease. This study aimed to investigate the molecular alterations between …
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