Search the literature by keyword, topic, or author. Filter to articles with full text available.
10021 results
<h4>Background/aim</h4>T-cell large granular lymphocyte leukemia (T-LGLL) is a rare, indolent lymphoproliferative disorder of cytotoxic T cells in the peripheral blood, bone marrow, and spleen. This analysis was conducted to characterize genomic alterations and highlight potential …
Read PDFThe Myanmar puddle frog, <i>Phrynoglossus myanhessei</i>, is a recently described, small dicroglossid frog distributed across central and southern Myanmar, typically inhabiting areas adjacent to small stagnant water bodies. With that new species description, rudimentary genome …
Read PDF<h4>Background</h4>Gaucher disease exhibits substantial genetic heterogeneity across populations. Asian populations remain understudied despite representing diverse genetic backgrounds. The systematic review was conducted to identify GBA1 mutations and genotype-phenotype correlations in Asian populations.<h4>Methods</h4>Following PRISMA guidelines, three …
Read PDFPlasmodium vivax is a major cause of malaria globally and has recently been transmitted locally in the USA. P. vivax produces homologs of host proteins, including cytokines such as macrophage migration inhibitory factor (MIF). MIF …
Read PDFAcute myeloid leukemia (AML) is a heterogeneous hematological malignancy characterized by extensive genomic alterations and molecular diversity, posing significant therapeutic challenges. Current treatment strategies lack precise predictive biomarkers for chemotherapy response, highlighting the need for …
Read PDFVascular malformations of the head and neck carry high morbidity because of their proximity to the airway, cranial nerves, sensory organs, and cerebral vasculature. Although the ISSVA classification of vascular anomalies has standardized diagnostic terminology, …
Read PDF<h4>Background</h4>D²EFT (Dolutegravir and Darunavir Evaluation in Adults Failing Therapy) was a phase 3b/4 randomized clinical trial designed to assess second-line treatment options systematically. This substudy evaluated the distribution of drug resistance mutations (DRMs) before treatment …
Read PDFBACKGROUND: Endometriosis (EMs) is a prevalent gynecologic disorder that often causes severe chronic pelvic pain and infertility. Although genome-wide association studies have identified common variants of EMs, the contribution of rare variants remains unclear. RESULTS: …
Read PDFArchaic introgression has shaped the modern human immune system, particularly components involved in RNA virus responses. In contrast, its contribution to DNA virus defense remains poorly understood. Here, we investigate the contribution of Neandertal- and …
Read PDFBACKGROUND: Wild emmer wheat (Triticum turgidum subsp. dicoccoides, WEW) was one of the first crops domesticated in the Neolithic revolution that shifted humanity to agrarian societies. Understanding its population genomics has both evolutionary significance and …
Read PDF<i>Calanthe aristulifera</i> is a critically endangered orchid species of profound horticultural and ecological significance. However, establishing its species integrity is complicated by frequent natural introgression with sympatric relatives, such as <i>C. sieboldii</i> and <i>C. discolor</i>. …
Read PDFBACKGROUND: The Fagaceae family includes key forestry species in temperate and Mediterranean ecosystems, many of which are increasingly impacted by drought stress and high temperatures, exacerbated by climate change. HSP90 proteins play a crucial role …
Read PDF[This corrects the article DOI: 10.3389/fmicb.2025.1714857.].
Read PDFNo abstract available.
Read PDFBACKGROUND: Y chromosome genetic markers, with strict paternal inheritance and lack of recombination, are particularly valuable tools for tracing male lineages. They complement autosomal analyses in forensic applications and anthropological inference by increasing resolution for …
Read PDFGenomic reanalysis can identify causative variants for rare diseases as patient phenotypes evolve and gene-disease knowledge expands. Despite its diagnostic value, routine reanalysis is limited by clinician capacity, lack of patient follow-up, data silos, cost, …
Read PDFNo abstract available.
Read PDFThe genus Apiospora has been relatively understudied in comparison to other filamentous fungi species, despite indications from previous research that this genus could yield valuable discoveries of novel enzymes and secondary metabolites applicable to various …
Read PDFBACKGROUND: Fertility was impaired in sleep deprivation (SD) male rats. Dutasteride (DUT), a 5-α reductase inhibitor, also had negative effects on fertility, however, its definite mechanisms were still unknown. To this end, SD male model …
Read PDF