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Full text 2025

Novel insights into the Leishmania infantum transcriptome diversity of protein-coding and non-coding sequences in both stages of parasite development using nanopore direct RNA sequencing

Emond-Rheault JG, Ferreira GR, Lavoie-Ouellet C, et al.

BACKGROUND: Leishmania relies on posttranscriptional control to regulate gene expression. Protein-coding genes are synthesised as polycistronic precursors that are processed into individual mRNAs by trans-splicing adding the spliced leader (SL) RNA to the 5’-end and …

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Transcriptomics
Full text 2025

ConsensuSV-ONT - A modern method for accurate structural variant calling

Pietryga A, Chiliński M, Gadakh S, et al.

Improvements in sequencing technology make the development of new tools for detection of structural variance more and more common. However, since the tools available for the long-read Oxford Nanopore sequencing are limited, and the selection …

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Nanopore Sequencing
Full text 2025

Transcriptomic and Epitranscriptomic Landscape of Integrated HTLV-1 in MT2 Cells

Wei S, Zhang B, Han J, et al.

Human T-lymphotropic virus type 1 (HTLV-1), the first human retrovirus identified, is linked to adult T-cell leukemia and HTLV-1-associated myelopathy/tropical spastic paraparesis. However, its post-transcriptional regulation remains poorly understood. Here, we used Oxford Nanopore direct …

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Transcriptomics