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The human microbiome is increasingly recognized as a key determinant of health and disease, yet methodological variability continues to limit reproducibility and clinical translation of findings. This review synthesizes current approaches in microbiome research, critically …
Read PDFBats are highly diverse mammals and known reservoirs of numerous zoonotic viruses. Their role in the ecology of emerging infectious diseases continues to be of significant interest. This study aimed to evaluate the occurrence of …
Read PDFShotgun metagenomics holds great potential for identifying parasite DNA in biological samples, but its effectiveness is limited by widespread contamination in publicly available reference genomes, which hinders accurate detection. In this study, we systematically quantify …
Read PDFAccurately predicting coding genes from metagenomic samples containing a high proportion of eukaryotic content remains a significant challenge. Novel and reliable methods for the simultaneous prediction of prokaryotic and eukaryotic microbial genes are crucial to …
Read PDFUrban wetlands are assumed to contribute to nitrous oxide (N<sub>2</sub>O) emissions; however, the microbial mechanisms underlying enhanced N<sub>2</sub>O fluxes in urban wetlands and differences in microbial responses between aquatic and soil compartments have not been …
Read PDF<h4>Background</h4>For the first time, a case of vertical transmission of TBEV in a dog associated with foetal death is described.<h4>Case presentation</h4>A six-year-old beagle bitch experienced foetal death from day 49 in pregnancy. A caesarean section …
Read PDFBACKGROUND: Next generation sequencing (NGS) has expanded virus detection capabilities beyond the limitations of sequence-specific methods. While mosquito collections in South Africa (SA) have been investigated for the major arbovirus genera (Alpha-, Orthobunya-, and Orthoflavivirus), …
Read PDFCable bacteria conduct long-distance electron transport in sediments but are not yet isolated in pure culture. We report the metagenome-assembled genome of <i>Candidatus</i> Electrothrix sp. NPCB-01 from Newport Bay, California. This 3.46-Mb genome encodes sulfur …
Read PDFRed raspberries have been shown to exert beneficial effects on immunometabolic health in numerous studies; however, these effects are subject to interindividual variability. Building on a previous transcriptomic-based clustering analysis from an 8-week randomized controlled …
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Read PDFProbiotics are live microorganisms that, when administered in adequate amounts, confer a health benefit on the host. One of the most common uses of probiotics is for prevention of antibiotic-associated diarrhea (AAD). Here we report …
Read PDFInflammatory bowel disease (IBD) involves chronic intestinal inflammation driven by gut-brain axis imbalance, fostering complications through an "inflammation-neuro-coagulation" triad. Current staging systems inadequately capture the dynamics of this multidimensional network. Therefore, integrated multi-omics analyses-including metagenomics, …
Read PDFThe analysis of high-dimensional microbiome multiomics datasets is crucial for understanding the complex interactions between microbial communities and host physiological states across health and disease conditions. Despite their importance, current methods, such as the microbe-metabolite …
Read PDFMicroorganisms are key players in the global cycling of nitrogen and carbon, controlling their availability and fluxes, including the emissions of the powerful greenhouse gases nitrous oxide and methane. Standard sequencing methods often reveal only …
Read PDF<h4>Background</h4>House dust mite (HDM) sensitization is a leading cause of allergic rhinitis and asthma worldwide, with <i>Dermatophagoides pteronyssinus</i>, <i>Dermatophagoides farinae</i>, and <i>Blomia tropicalis</i> being the primary allergenic species typically associated with indoor environments. Even effective …
Read PDFRelational databases offer an efficient solution for storing and retrieving complex data sets, yet the requirement for SQL programming expertise presents a significant challenge for many life science users. We explore whether a cutting-edge large …
Read PDFIdiopathic normal pressure hydrocephalus (iNPH), a leading cause of reversible dementia in older adults, is marked by ventriculomegaly, gait disturbances, cognitive decline, and urinary incontinence. Emerging evidence suggests that gut dysbiosis (microbial imbalance) may influence …
Read PDFThe human gut microbiome plays a crucial role in human health, adapting and responding to changes in diet, environment, and lifestyle. However, current microbiome research is heavily biased toward high-income countries, leaving regions such as …
Read PDFThe river Yamuna is one of the most polluted rivers in India and is heavily impacted by urban, industrial, and agricultural inputs. In this study, shotgun metagenomics was used to investigate microbial diversity and functional …
Read PDF<h4>Background</h4>The Baltic Sea receives petroleum hydrocarbons from various point sources. The degradation of these contaminants in the environment is typically facilitated by a variety of microorganisms that possess a range of genes and metabolic functions …
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