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<h4>Key points</h4>Long-read-metagenomic sequencing is the best method for analyzing the sinus microbiome. 16s-rRNA-sequencing (both long and short read) results in PCR amplification bias that significantly distorts the sinus microbiome.
Read PDFLung adenocarcinoma (LUAD) is a predominant subtype of lung cancer and is highly lethal. The lung tissue microbiota has been implicated in lung cancer biology but remains incompletely defined at early stages. We enrolled 40 …
Read PDFTomato is a staple crop and an excellent model to study host-microbiota interactions in the plant food chain. In this study, we describe a "lab-in-the-field" approach to investigate the microbiota of field-grown tomato plants. High-throughput …
Read PDFAromatic hydrocarbons (AHs) are persistent environmental pollutants with high toxicity. Bacterial degradation of AHs provides a sustainable and cost-effective approach for the remediation of sites contaminated with both mono- and polycyclic aromatic hydrocarbons. Aerobic degradation …
Read PDFPregnancy failure or abortion in dairy cattle is a major reproductive concern that affects animal welfare and the dairy industry's economic stability. Pathogens are a key factor contributing to this issue. Accurate diagnosis is essential …
Read PDFObesity is a heterogeneous condition comprising a continuum of phenotypes with various metabolic and inflammatory profiles. Metabolically healthy obesity (MHO) identifies individuals with obesity but a relatively preserved metabolic state, although little is known about …
Read PDFThe early-life development of the gut microbiome in broiler chickens is a dynamic ecological process with significant implications for host physiology and productivity. Using 388 genome-resolved metagenomic and 61 metatranscriptomic samples across two replicated trials, …
Read PDFElucidating the molecular architecture of microbial terroir is vital for precision fermentation, yet functional decoupling between taxonomic abundance and in situ expression remains a fundamental challenge. To resolve this "abundance-activity paradox," we integrated metaproteomics, metabolomics, …
Read PDFFreshwater lakes are dynamic ecosystems, with varying oxygen dynamics that influence microbiome structure, composition, and transcriptomic activity. In many freshwater studies, ecological function and abundance metrics are used to discover keystone species; however, it is …
Read PDF<h4>Background</h4>Chronic atrophic gastritis (CAG) is related to the body's microbial and metabolic systems. Combined studies of microbiome and metabolomics can clarify the mechanisms of disease occurrence and progression. We used 16S rRNA sequencing, metagenomics sequencing …
Read PDFPopulation-specific variation in animal microbiomes is well documented, yet the functional consequences and underlying mechanisms remain poorly understood. To address this, we conducted genome-resolved metagenomic analyses on gut and skin microbiomes from four populations of …
Read PDFEntomophagy is increasingly popular, and Acheta domesticus offers an ecologically sustainable protein alternative, but the effects on the human gut microbiome need further investigation. In this study, we investigated the impact of the intake of …
Read PDFHigh-throughput sequencing has provided unprecedented insights into microbial biodiversity in marine and other ecosystems. However, most sequencing-based studies report only relative (compositional) rather than absolute abundance, limiting their application in ecological modeling and biogeochemical analyses. …
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Read PDFColorectal cancer (CRC) is closely linked to gut microbiota dysbiosis. We synthesize evidence that carcinogenic microbes promote CRC through chronic inflammation, bacterial genotoxins, and metabolic imbalance, highlighting key pathways involving <i>Fusobacterium nucleatum</i>, <i>pks</i> <sup>+</sup> <i>Escherichia …
Read PDF<h4>Study objectives</h4>We aim to analyze the microbiota composition in Restless Legs Syndrome (RLS) patients and its relationship with the different RLS phenotypes.<h4>Methods</h4>We recruited idiopathic RLS (RLS) and insomnia (INS) patients and healthy subjects (CTRL). Validated …
Read PDFMetaproteomics, an emerging field among the omic techniques, holds great promise for unraveling the function of microbiomes in host health and our environment. Metaproteomics can also be a valuable addition to multiomics studies of the …
Read PDF<h4>Background</h4>Spontaneous preterm birth (sPTB) remains a major cause of neonatal morbidity and mortality. We used integrated metagenomics and untargeted metabolomics to identify vaginal microbial and host metabolic signatures associated with sPTB in Chinese women.<h4>Methods</h4>Vaginal swabs …
Read PDFFlooding events alter microbial communities, impacting soil health and ecosystem recovery. This study examined the 2024 Bangladesh floods' effects on microbial diversity in agricultural and residential soils. We collected paired soil samples from six flooded …
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