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Recent advances in spatial transcriptomics have highlighted the need for integrating spatiotemporal transcriptomics data, defined as spatially resolved gene expression profiles captured across sequential time points in developmental or regenerative processes. We present STIFT (SpatioTemporal …
Read PDF<h4>Objective</h4>This study aimed to elucidate the potential targets and molecular mechanisms underlying arecoline-induced oral submucous fibrosis through integrated transcriptomic profiling and experimental validation.<h4>Methods</h4>Transcriptomic sequencing was first employed to identify key pathways and targets influenced by …
Read PDFEstimating tumour immune infiltration is critical for understanding cancer biology and predicting patient response to surgery and immunotherapy. A wide array of experimental platforms supports various computational approaches for quantifying tumour-infiltrating lymphocytes and immune infiltration …
Read PDFMetabolic dysfunction-associated steatotic liver disease (MASLD) is a chronic condition impacting over 30% population, yet the dynamic changes in macrophage composition from steatosis to steatohepatitis (metabolic dysfunction-associated steatohepatitis, MASH) remain unclear. Here, by integrating single-nucleus …
Read PDF<h4>Background</h4>High-grade serous ovarian cancer (HGSOC) is the most lethal ovarian cancer subtype, responsible for ~ 70% of ovarian cancer-related deaths and marked by late-stage diagnosis and frequent platinum resistance. Although transcriptomic profiling enables molecular stratification …
Read PDFPeripartum cardiomyopathy (PPCM) is a rare form of acute heart failure that develops in women toward the end of pregnancy or early postpartum. No effective, specific treatment for PPCM is available and heart transplantation or …
Read PDFSpatiotemporal heterogeneity is recognized as a key driver of functional diversity in tissues. Spatial transcriptomics, which integrates high-throughput transcriptomics with high-resolution tissue imaging, enables the precise mapping of gene expression patterns at the tissue section …
Read PDF<h4>Background</h4>Fungal infections, in particular those caused by <i>Aspergillus niger</i> (<i>A. niger</i>), pose a severe threat to human health, and the situation has been getting worse because of increasing resistance against the frontline triazole antifungals. Sea …
Read PDFPolychlorinated biphenyls (PCBs) are highly stable synthetic organic compounds that are present in air, water, and soil. PCBs have been identified in post-mortem human brains, indicating a possible link between environmental factors and disease risk. …
Read PDF<h4>Background</h4>Per- and polyfluoroalkyl substances (PFAS), persistent environmental contaminants, are associated with increased Prostate cancer (PCa) risk. However, their molecular mechanisms are poorly defined.<h4>Methods</h4>We employed a comprehensive computational and experimental framework. The toxicological profiles of PFOA …
Read PDFHER2-positive breast cancer exhibits marked genomic instability and heterogeneity, yet the clonal architecture and copy number variation (CNV) dynamics between ductal carcinoma in situ (DCIS) and invasive ductal carcinoma (IDC), remain poorly understood. We analyzed …
Read PDFBACKGROUND: Melanoma, a type of skin cancer that can spread to other parts of the body, currently lacks highly precise individualized treatment options. METHODS: We performed multi-omics integration on The Cancer Genome Atlas Skin Cutaneous …
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Read PDFOn September 9th, 2025, the 3rd Workshop on Tertiary lymphoid structures (TLS) took place in Utrecht as pre-meeting to CICON2025. Advances in TLS biology, diversity, and clinical significance are rapidly reshaping the field. The studies …
Read PDFChemical exposure in real-world settings occurs predominantly as mixtures, whereas toxicological assessment has long been shaped by single-substance paradigms. As interest in more human-relevant and mechanistically informative testing strategies has grown, new approach methodologies (NAMs) …
Read PDF<h4>Background</h4>Neuroimaging evidence indicates brain alterations in rhegmatogenous retinal detachment (RRD), but the molecular and neurochemical correlates of these macroscale patterns remain unclear.<h4>Methods</h4>We examined gray matter volume (GMV), intrinsic neural timescale (INT) and structural covariance network …
Read PDFSpatial transcriptomics (ST) represents a transformative approach in cancer research, offering high-resolution insights into the spatial organization of gene expression within tissues, particularly relevant for the complex tumor microenvironment (TME) of oral squamous cell carcinoma …
Read PDFThe liver circadian clock coordinates hepatic lipid metabolism, bile acid synthesis, and glucose homeostasis through interlocking transcription-translation feedback loops. Disruption of this temporal organization is increasingly recognized as a shared pathological feature across the chronic …
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