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Animals can provide meaningful context for human single-cell data. To transfer information between species, we propose a deep learning approach that pre-trains a conditional variational autoencoder on animal data and transfers its final encoder layers …
Read PDF<h4>Purpose</h4>Neuroblastoma (NB) is the most common extracranial solid tumor in children with poor overall survival. Increasing evidence indicates that telomeres contribute to tumorigenesis and influence cancer prognosis. However, the biological and clinical implications of telomere-related …
Read PDFSevere skin injury in humans typically heals through fibrotic remodelling rather than true regeneration, resulting in permanent loss of appendages, sensory function, and tissue architecture. Over the past decades, advances in bulk, single-cell, and spatial …
Read PDFPrimordial germ cells (PGCs), the precursors of the germline, have unique cellular characteristics to undergo long-distance migration to the embryonic gonads and have the potential to differentiate into somatic cells. Among the animal models studying …
Read PDFSingle-cell multimodal omics technologies have empowered the profiling of complex biological systems at a resolution and scale that were previously unattainable. These biotechnologies have propelled the fast-paced innovation and development of data integration methods, leading …
Read PDFThe cerebellar rhombic lip neurogenic niche is critical for glutamatergic neurogenesis, and dysregulated differentiation of rhombic lip lineage cells is hypothesized to cause medulloblastoma (MB), a malignant pediatric cancer lacking targeted therapies. Humans have structural …
Read PDFOral squamous cell carcinoma (OSCC) is a highly aggressive head and neck malignancy with a poor prognosis associated with its complex tumor microenvironment. Cancer-associated fibroblasts (CAFs) contribute to tumor progression by secreting various signaling molecules. …
Read PDF<h4>Background</h4>Colorectal cancer (CRC) remains a major health threat with poor prognosis in advanced stages. The transcription factor ETV4 (ETS translocation variant 4) has been implicated in various cancers, but its specific role, prognostic value, and …
Read PDF<h4>Background</h4>CD27<sup>+</sup> cytotoxic T cells play critical roles in anti-tumor immunity, yet their heterogeneity and functional states within the colorectal cancer (CRC) tumor microenvironment remain poorly characterized. Understanding the molecular mechanisms underlying T cell exhaustion is …
Read PDFMultiple myeloma (MM) is a heterogeneous hematologic cancer marked by clonal plasma cell expansion in the bone marrow. Although treatments have improved, relapse remains common due to clonal evolution, tumor microenvironment changes, ultimately leading to …
Read PDFDrug-induced liver injury remains a major obstacle in pharmaceutical development and a leading cause of acute liver failure, underscoring the need for predictive and human-relevant in vitro models. Acetaminophen, a widely used analgesic with well-characterized …
Read PDFAlthough microsatellite instability (MSI) is traditionally regarded as a binary trait, growing evidence indicates that it exists on a continuum, with higher intensity of MSI correlating with better prognosis. However, accurate quantification of MSI intensity …
Read PDFFever elevates body temperature to enhance immune response; however, intracellular temperature can fluctuate by up to 15 °C, suggesting a previously unrecognized layer of thermal regulation. While hyperthermia has long been exploited in medicine, how …
Read PDFSingle-cell multiomics technologies provide unprecedented opportunities to dissect cellular heterogeneity by capturing multidimensional information on complex cellular states and regulatory networks. However, challenges such as high dimensionality, extreme data sparsity, and modality-specific discrepancies hinder the …
Read PDFLung adenocarcinoma (LUAD) harboring distinct actionable oncogenic mutations exhibits differential responses to immune checkpoint inhibitors (ICI); however, the underlying mechanisms remain elusive. Here, we report comprehensive single-cell spatial atlases of tumors from 38 LUAD patients, …
Read PDFPancreatic cancer remains a highly lethal malignancy with limited therapeutic efficacy and untapped immunotherapeutic potential, largely constrained by immune cell heterogeneity in the tumour microenvironment. Tumour-associated macrophages (TAMs), especially tissue-resident macrophages (TRMs), exert complex regulatory …
Read PDF<h4>Background</h4>Decades of immunological and genetic studies highlight CD4<sup>+</sup> T cells as initiators of central nervous system (CNS) pathology in individuals who develop multiple sclerosis (MS). A low-frequency CD4<sup>+</sup> T-cell population termed T helper 17.1 (Th17.1) …
Read PDFBACKGROUND: Subcutaneous adipose tissue (SAT), the key human fat depot for cardiometabolic health, exhibits high cellular heterogeneity. However, the contributions of contexts and cardiometabolic diseases (CMDs) to this heterogeneity are poorly understood, especially in admixed …
Read PDFBACKGROUND: Arthritis ranks as a primary contributor to global disability, with synovitis representing a common pathological feature across all types of arthritis. Given that macrophages constitute the predominant inflammatory cells in arthritic synovium, deciphering their …
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