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Advances in single-cell and spatial technologies have transformed the dissection of cell composition and tissue architecture in complex biological systems. However, identifying rare cells critical to disease pathogenesis and biological processes remains difficult, as their …
Read PDFTo identify the cell types that are infected with KSHV and the immune interactions in Kaposi sarcoma (KS) lesions, we performed spatial transcriptomics with seven KS skin tumors. We used a single-cell RNA-sequencing reference data …
Read PDFTumor heterogeneity and complex microenvironment interactions drive malignant progression and therapeutic resistance. Traditional omics technologies struggle to capture this complexity due to the loss of spatial molecular context. Spatial multi-omics technologies enable the simultaneous <i>in …
Read PDFA 4-dimensional spatial gene expression atlas of Hordeum vulgare (barley) grain development and germination was generated using spatial transcriptomic analysis of serial sections to reconstruct transcript abundance in 3 physical dimensions and with temporal kinetics. …
Read PDFThe main sources of circulating erythropoietin (Epo) in the adult are kidney Norn cells, a recently identified interstitial cell type capable of becoming renal Epo-producing (REP) cells following a local decrease in tissue oxygenation. REP …
Read PDF<b>Background</b>: Follicular lymphoma (FL) and diffuse large B-cell lymphoma (DLBCL) exhibit substantial heterogeneity, reflecting the diversity of the germinal center (GC). Histologic transformation of FL to DLBCL is associated with poor prognosis, yet robust biomarkers …
Read PDFDrought stress is a major constraint on global agriculture, exacerbated by climate change and increasing water scarcity. Conventional strategies such as breeding and genetic engineering have improved drought tolerance in crops, yet their scalability and …
Read PDFThe clinical management of refractory pituitary neuroendocrine tumors (PitNETs) remains a formidable challenge due to pervasive resistance to traditional therapies. Current therapeutic failures appear closely associated with lineage-specific immune heterogeneity and the unique "hypovascular-fibrotic" physical …
Read PDF<h4>Background</h4>Obesity, a chronic metabolic disease, lacks effective treatments. Intermittent fasting (IF), especially time-restricted feeding (TRF), shows promise, yet the comparative molecular effects of different regimens remain unclear. This study examined their impact on 3T3-L1 adipocytes …
Read PDF<h4>Aim of the study</h4>To analyze the chemical components of BSCO, evaluate its effects on lung cancer through vivo and vitro experiments, reveal its underlying mechanism in a rat model of LC.<h4>Methods</h4>Ultra-high performance liquid chromatography with …
Read PDFThe application of virtual histology in determining endometrial receptivity has been effectively demonstrated in a recent publication. This commentary aims to elucidate previous research in this area and highlight the essential conditions for optimizing this …
Read PDFAlzheimer's disease (AD) is characterized not only by neuronal dysfunction but also by profound remodeling of the brain microenvironment, including immune-glial activation and metabolic dysregulation. Increasing evidence also implicates neurosteroid-related pathways in AD and dementia. …
Read PDF<h4>Background & objective</h4>Emerging viral infections can initiate a global pandemic with high mortality. Understanding the immunopathogenesis of these viruses is critical to developing effective strategies for managing/preventing such outbreaks.<h4>Methods</h4>Transcriptomics analysis was performed in a UAE …
Read PDFHigh-throughput spatial transcriptomics (ST) now profiles hundreds of thousands of cells or locations per section, creating computational bottlenecks for routine analysis. Sketching, or intelligent sub-sampling, addresses scale by selecting small, representative subsets. While effective for …
Read PDF<b>Background:</b> Polycystic ovary syndrome (PCOS) is a complex endocrine-metabolic disorder characterized by interconnected dysregulation of steroidogenesis and insulin signaling. Multi-target therapeutic strategies are increasingly needed to address its heterogeneous pathophysiology. <b>Methods:</b> An integrative approach combining …
Read PDFAdvances in organoid and other three-dimensional culture systems, single-cell and spatial transcriptomics, multi-omics, and high-resolution imaging are reshaping our understanding of the cellular origins and evolutionary trajectories of glioblastoma. When integrated with modern data science …
Read PDFNeutrophils are key first responders in the host response to <i>Clostridioides difficile</i> infection (CDI). Although a high number of tissue and blood neutrophils clearly correlates with adverse outcomes in CDI patients, their functional role remains …
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