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Liposarcoma (LPS) is the most common soft-tissue sarcoma in adults, and well-differentiated liposarcoma (WDLPS) and dedifferentiated liposarcoma (DDLPS) are the most frequent subtypes. These LPSs are considered to develop due to disturbances in the adipogenic …
Read PDF<h4>Importance</h4>Most pancreatic cancer (PC) cases are diagnosed at a late stage, leading to poor prognosis. New-onset diabetes (NOD) increases the risk of PC by 6- to 8-fold within the first 3 years of diagnosis. This …
Read PDFInfants with severe bronchiolitis (i.e., bronchiolitis requiring hospitalization) face increased risks of respiratory diseases in childhood. We conduct epigenome-wide association studies in a multi-ethnic cohort of these infants. We identify 61 differentially methylated regions in …
Read PDFThe detection and retrieval of specific single cells within a cell population is useful for elucidating cellular function as well as early-stage cancer diagnosis by detecting circulating tumor cells. Microcapillaries are used to retrieve specific …
Read PDFCervical cancer remains a significant global health burden, with chemoradioresistance representing a major obstacle to successful treatment. To elucidate the mechanisms underlying this resistance, we established a unique pair of isogenic primary cervical cancer cell …
Read PDFThe circadian clock drives rhythmic physiological variations, making accurate clock-phase measurement essential. Single-sample phase inference from bulk RNA is an exciting alternative to time-series methods, but its applicability to single cells remains unclear. Using multiplexed …
Read PDFSingle cell RNA sequencing is a tool for evaluating the specific transcriptome usage of different cell types within an organism. By tagging mRNA molecules from single cells or nuclei, a non-biased assay of the active …
Read PDFRare cell heterogeneity significantly impacts diagnosis, prognosis, therapeutic options and responses, particularly in diverse diseases like cancer. While single-cell analysis is the most effective route, isolating cells individually with high selectivity, purity, efficiency and throughput …
Read PDFSubchondral bone marrow lesions (BMLs) constitute a pathognomonic imaging feature of both incipient and progressive osteoarthritis (OA). However, the pathological features and molecular mechanisms underlying BMLs remain poorly characterized. Here, we innovatively established and dynamically …
Read PDFSingle-cell studies rely on advanced integration methods for complex datasets affected by batch effects from technical factors alongside meaningful biological variation. Silhouette is an established metric for assessing unsupervised clustering results, comparing within-cluster cohesion to …
Read PDFEmbedding is the key step in single-cell Hi-C (scHi-C) analysis which relies on capturing biological meaningful heterogeneity at various levels of genome architecture. To understand the strength and limitations of existing tools in various applications, …
Read PDFCannabis use is prevalent among individuals living with HIV in the United States, but the impact of cannabis exposure on the reservoir of latently infected cells that persists during antiretroviral therapy (ART) remains unclear. To …
Read PDF<h4>Background</h4>The study of three-dimensional (3D) genome structures at the single-cell level is crucial for understanding cell-to-cell variability. However, it is challenging to reconstruct the 3D structures of the whole genome based on single-cell Hi-C data …
Read PDFAtherosclerosis, a major cause of cardiovascular diseases, is characterized by the buildup of lipids and chronic inflammation in the arteries, leading to plaque formation and potential rupture. Despite recent advances in single-cell transcriptomics (scRNA-seq), the …
Read PDFGraves' disease (GD) is an autoimmune disorder primarily targeting the thyroid tissue. While major histocompatibility complex (MHC)-dependent B cell activation and thyroid-stimulating hormone receptor (TSHR) autoantibody production are central to GD, the intrathyroidal immune landscape …
Read PDF<h4>Background</h4>The transformation of non-small cell lung cancer (NSCLC) into small cell lung cancer (SCLC) is a recognized treatment resistance mechanism, most often arising from EGFR-mutant lung adenocarcinoma (LUAD). However, the underlying mechanisms of transformation remain …
Read PDFIschemic stroke (IS) remains a leading cause of death and disability, with limited effective treatments in the acute phase. Mitophagy, the selective degradation of damaged mitochondria, plays a crucial role in cellular homeostasis and survival …
Read PDF<h4>Background</h4>Notch1 exhibits a high mutation rate in head and neck squamous cell carcinoma (HNSCC), but its functional role in nasopharyngeal carcinoma (NPC) invasion and metastasis remains incompletely understood. This study systematically investigates the function and …
Read PDF<h4>Background</h4>Osteoporosis is characterized by reduced bone mineral density and disrupted bone microstructure, leading to an increased risk of fractures. This study aimed to investigate the role of B cell subpopulations in osteoporosis and their effects …
Read PDF<h4>Introduction</h4>Alternative splicing (AS) of mRNAs is a highly conserved mechanism which can greatly expand the functional diversity of the transcriptome. Aberrant splicing underpins many diseases, and a better understanding of AS can provide insights regarding …
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