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<h4>Background</h4>Interferons play a central role in antiviral defense, but their dysregulation contributes to inflammation and immune dysfunction in respiratory viral infections, including COVID-19. While interferon-stimulated genes (ISGs) are essential effectors of this response, their expression …
Read PDF<h4>Objective</h4>This study aimed to develop and validate a machine learning model integrating multi-omics and radiomics data to improve diagnostic accuracy and identify potential biomarkers for Rheumatoid Arthritis-Associated Interstitial Lung Disease (RA-ILD).<h4>Methods</h4>A total of 278 patients …
Read PDFAcne, the most prevalent inflammatory skin condition globally, lacks comprehensive understanding of its cellular and molecular mechanisms. This research integrates single-cell transcriptomics with spatial immunofluorescence to detail cellular composition and functional states in healthy skin, …
Read PDF<h4>Background</h4>Hepatocellular carcinoma (HCC) remains a leading cause of cancer-related mortality, with limited efficacy of current therapies in advanced cases. As a key risk factor for HCC, liver fibrosis may influence tumor progression and immune responses. …
Read PDFUsing biomedical foundation models (FMs) for inference on small cohorts, represents a promising and practical route to advance drug response biomarker discovery and target identification. Here, we demonstrate this via an innovative data-driven inference workflow, …
Read PDFDuring the hair cycle and wound regeneration, various developmental transcriptomic features are reactivated. Consequently, studying skin development provides critical insights into both fundamental biology and skin regeneration. However, chromatin accessibility during skin development remains underexplored. …
Read PDFAdvanced imaging and single-cell omics technologies are fundamentally transforming developmental biology research, shifting it from static observation to dynamic, spatially resolved systems biology. Super-resolution microscopy breaks the diffraction barrier to visualize nanoscale subcellular dynamics, while …
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Read PDFRecent advances in spatial omics technologies have provided unprecedented insight into tissue spatial organization, but challenges remain in aligning spatial slices and integrating complementary single-cell and spatial data. Here, we propose TOAST (topography-aware optimal alignment …
Read PDFDeciphering cellular microenvironments at atlas scale remains challenging because molecular identity, spatial context, and platform heterogeneity are tightly coupled. Here we present CellNiche, a scalable contrastive-learning framework that identifies and characterizes cellular microenvironments from spatial …
Read PDFThe progression from metabolic dysfunction-associated steatotic liver disease (MASLD) to metabolic dysfunction-associated steatohepatitis (MASH) is a critical link leading to cirrhosis and hepatocellular carcinoma. Yet the responsible cellular programs remain unclear. We integrated public single-cell, …
Read PDFAn important task in the analysis of spatially resolved transcriptomics (SRT) data is to identify spatially variable genes (SVGs), or genes that vary in a 2D space. Current approaches rank SVGs based on either $ …
Read PDFThe process of arterial atherosclerosis is characterised by accumulation of lipids and fibrous material with accompanying inflammation. As plaques progress, they restrict blood flow and cause rupture, which results in life threatening organ ischemia and …
Read PDF<h4>Introduction</h4>The objective of this study was to evaluate the fetal programming effects of removing maternal heat abatement during late gestation on offspring growth, thermotolerance, physiological responses, and liver gene expression during the backgrounding phase.<h4>Methods</h4>Fifty-six Angus-cross …
Read PDFSpatial transcriptomics (ST) facilitates the exploration of biological tissue structures and functions within spatial context. Slice alignment and integration are prevalent for analyzing ST data, and current algorithms either focus on adjacent slices or require …
Read PDFTranslating pathogen-specific molecular insights into effective treatments remains a significant challenge, particularly for drug-resistant wound infections. In this study, we develop a nitrogen-doped iron/cobalt dual-atom catalyst (FeCo-N-DAC) with high metal loading (Fe > 5.4%, Co …
Read PDF<h4>Introduction</h4>Hepatocellular carcinoma (HCC) is a common malignant tumor, is characterized by an early stage that is not easy to diagnose and a high mortality rate in the late stage, which is a serious threat to …
Read PDFDurio zibethinus, commonly known as the "king of the fruits," is widely cultivated in Southeast Asia, contributing significantly to the region's economy. In addition to commercial cultivars, numerous local edible durian species are also found …
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