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<h4>Background</h4>Cervical cancer ranks as the fourth most common malignancy among women worldwide, with approximately 604,000 new cases and 342,000 deaths annually. Despite advances in HPV vaccination and screening programs, significant challenges remain in diagnostic accuracy, …
Read PDFAge-related loss of innervation in skeletal muscle is a key driver of sarcopenia. We investigated the role of calcium-dependent phospholipase A<sub>2</sub> (cPLA<sub>2</sub>) in denervation-atrophy. cPLA<sub>2</sub> mediates the release of polyunsaturated fatty acid substrates, and the …
Read PDFOmics technologies can uncover the complex regulatory mechanisms of living systems at multiple levels, including genes, transcripts, proteins, metabolites and immune networks. They also provide an integrative framework to study how cells interact with their …
Read PDFLymph node metastasis (LNM) is a critical prognostic and therapeutic determinant in small cell lung cancer (SCLC), yet its spatial cellular ecosystem remains poorly understood. Here, we perform single-cell spatial transcriptomics using the CosMx Spatial …
Read PDFDespite enabling high-resolution mapping of gene expression within tissues, spatial transcriptomics (ST) still faces challenges in accurately segmenting spatial domains due to complex tissue architecture and limitations of current methods. Most approaches rely on local …
Read PDFIntratumor, intertumor and temporal heterogeneity shapes capricious therapeutic response and complicates personalized treatment. It reflects interacting genetic, epi-genetic, transcriptional, and microenvironmental variation. Patient derived organoids (PDOs) are three-dimensional, patient anchored cultures that preserve key tumor …
Read PDFBACKGROUND: The complex metabolic and immune characteristics of ovarian cancer and their interconnections can promote tumor immune evasion, ultimately leading to immunotherapy failure. A comprehensive understanding of these relationships can inform the development of diagnostic …
Read PDFThis study presents a comprehensive single-cell and spatial transcriptomic atlas of prostate cancer progression, integrating 127 single-cell RNA sequencing samples and 9 spatial transcriptomics profiles spanning the disease continuum from healthy prostate to neuroendocrine carcinoma. …
Read PDFSignificant efforts have harvested a sophisticated understanding of Alzheimer's disease (AD) including amyloid beta (Aβ) cascade mechanisms, although effective treatment for reversing or stopping AD progression is not available. This study reports that ferul enanthate …
Read PDFProtein function is inherently spatial: the same molecule can elicit distinct biological outcomes depending on its localization, interacting partners, and surrounding microenvironment. Spatial proteomics enables systematic <i>in situ</i> characterization of protein localization, abundance, and interactions …
Read PDFGastrointestinal nematode (GIN) infections are the most prevalent parasitic diseases in grazing sheep worldwide, causing significant productivity losses, high mortality and, as a result, economic losses and emerging animal welfare concerns. Conventional control strategies, primarily …
Read PDF[This corrects the article DOI: 10.3389/fonc.2025.1614058.].
Read PDFBACKGROUND: Endometriosis encompasses heterogeneous lesions, primarily peritoneal and ovarian subtypes, with distinct immunological and fibrotic features. The subtype-specific roles of the immune microenvironment in pathogenesis remain unclear. Integrated analysis combining high-resolution cellular atlases with spatial …
Read PDFAlzheimer's disease (AD) is increasingly understood as a disorder driven not only by amyloid and tau pathology but also fundamentally shaped by underlying genetic mutations. By integrating multiple AD gene expression datasets with machine learning …
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Read PDFAdult acute lymphoblastic leukemia (ALL) is a highly heterogeneous hematologic malignancy where treatment response and relapse risk do not exclusively rely on the identification of genetic lesions but also on dynamic biological states sustained by …
Read PDFSpatial transcriptomics technologies have significantly enhanced the analysis of gene expression profiles by retaining the spatial information of intact tissue sections and enabling the possibility of a more profound comprehension of tissue structures and cellular …
Read PDF<h4>Background</h4>Bladder cancer (BLCA) is a malignant tumor originating from the urothelial lining, characterized by a complex tumor microenvironment (TME) and heterogeneous tumor mutation burden (TMB). Cancer-associated epithelial cells (EpiCs) exhibit substantial heterogeneity during BLCA initiation …
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