Search the literature by keyword, topic, or author. Filter to articles with full text available.
10021 results
Porcine epidemic diarrhea (PED) is a severe viral disease caused by the porcine epidemic diarrhea virus (PEDV), leading to huge economic losses in the swine industry. Identifying therapeutic targets has long been a critical challenge …
Read PDFComprehensive analyses of multiple biological components including nucleic acids, proteins, metabolites, and lipids (i.e. "multiomics") provide unique insights into complex biological processes. Combining insights from these components through multiomics data integration enhances the depth and …
Read PDFThe autoantibody reactome refers to the multidimensional repertoire of antibody reactivities against self-antigens across the human proteome or selected antigenic compartments. This offers a scalable systemic layer for precision immunology across spontaneous autoimmunity and treatment-induced …
Read PDFMetastatic breast cancer (MBC) remains the primary cause of mortality in breast cancer patients, driven by tumor heterogeneity, cellular evolution, and therapy-resistant clones. Traditional bulk transcriptomics, although informative, fail to capture rare subpopulations and context-specific …
Read PDFMetastasis remains the leading cause of cancer mortality, yet the factors that determine metastatic competence and the timing of its acquisition are not well understood. Using human breast cancer cohorts and multi-omics in preclinical models, …
Read PDFLichen planus (LP) is a chronic inflammatory disease of the skin and mucous membranes, marked by T cell infiltration and keratinocyte apoptosis. However, its immune microenvironment remains poorly understood. Using single-cell RNA sequencing, spatial transcriptomics, …
Read PDF<h4>Background</h4>Hepatocellular carcinoma (HCC) is the fourth leading cause of cancer-related death worldwide and shows significant heterogeneity. Cadherin 13 (CDH13) is abnormally expressed in various malignancies, but its role in HCC and the tumor microenvironment remains …
Read PDF<h4>Purpose</h4>Dry eye disease (DED) is a multifactorial chronic disorder of the ocular surface, characterized by reduced tear secretion, tear film instability, and inflammation. Oxidative stress is pivotal in DED pathogenesis. Qingxuan Runmu Yin (QRY) has …
Read PDFAge-related skeletal muscle deterioration, referred to as sarcopenia, poses significant risks to astronaut health and mission success during spaceflight, yet its multisystem drivers remain poorly understood. While terrestrial sarcopenia manifests gradually through aging, spaceflight induces …
Read PDFHigh‑throughput transcriptomic technologies offer a systems‑level approach to unravel the mechanisms of complex immune disorders. Inflammatory Bowel Disease (IBD), a classic example of such disorders, involves intricate interactions between genetics, microbiota and immune dysfunction. The …
Read PDFNo abstract available.
Read PDF<h4>Introduction</h4>Chronic alcohol consumption exacerbates the progression of periodontitis, the sixth most prevalent global disease affecting over 740 million people, though its underlying mechanisms remain poorly understood.<h4>Objective</h4>The study aims to elucidate the impact and mechanisms of …
Read PDFCellular morphology is tightly linked to function, but how subcellular transcript localization contributes remains unclear. Using microglia, the brain's resident macrophages, as a model, we combined multiplexed error-robust fluorescence in situ hybridization with immunohistochemistry to …
Read PDFGlioblastoma multiforme (GBM) is the most aggressive primary brain tumor in adults, with poor survival despite multimodal therapy. Tumor heterogeneity, immune evasion, and recurrence limit the effectiveness of current treatments, necessitating novel therapeutic strategies. Vaccine-based …
Read PDFSpatial transcriptomics enables the detection of rare or transitional tumor states not captured by bulk transcriptomics or immunohistochemistry (IHC). However, translating these spatially defined states into clinically relevant biomarkers is challenging, because signals from minor …
Read PDFScreening and molecular characterization of human intestinal pathologies such as colorectal cancer (CRC) currently depends on colonoscopy, an invasive procedure associated with risks and poor adherence. A non-invasive method that captures host molecular changes could …
Read PDFSepsis is a systemic response to infection with life-threatening consequences such as hemolysis, a predictor of mortality risks for the disease. Here, by measuring organism-wide changes in gene expression, we discovered that the secreted phospholipase …
Read PDF