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Polycyclic aromatic hydrocarbons (PAHs), such as benzo[a]pyrene (B[a]P), are major risk factors for lung cancer and other diseases, acting through the aryl hydrocarbon receptor (AHR). Alveolar macrophages (AMs) help regulate the lung microenvironment by responding …
Read PDF<h4>Aims</h4>Mammalian genomes encode 12 proteins that contain a CXXC zinc finger domain. Most members of this family are large multi-domain proteins that function in the control of DNA methylation and histone methylation patterns. CXXC5 is …
Read PDFThis Special Issue invited the submission of sports nutrition-based manuscripts that advanced scientific understanding and provided novel insights on all aspects of performance and recovery [...].
Read PDFIntrahepatic cholangiocarcinoma (iCCA) is a rare yet aggressive malignancy characterized by late-stage diagnosis and poor prognosis. Recent advancements in multi-omics technologies have significantly enhanced the understanding of the molecular features and complex biological mechanisms of …
Read PDFMycorrhizal symbioses represent one of the most widespread and ecologically significant plant-microbe interactions, shaping plant nutrition, stress resilience, and ecosystem functioning. Beyond their role in nutrient exchange and systemic defense, growing evidence suggests that these …
Read PDFBACKGROUND: Cardiometabolic diseases are among the leading causes of increasing morbidity and mortality worldwide. However, current population-based dietary recommendations do not sufficiently account for biological differences between individuals and therefore do not have the same …
Read PDFHow genes respond to external signals is poorly understood, with transcription factors and histones proposed as mediators of signals to RNA polymerase II (Pol II). However, recent work shows that Pol II is the direct …
Read PDFDNA methylation is a fundamental epigenetic modification that regulates gene expression and maintains genomic stability. Consequently, DNA methylation remains a key biomarker in cancer research, playing a vital role in diagnosis, prognosis, and tailored treatment …
Read PDFProstate cancer is a common malignancy that in 5%-30% leads to treatment-resistant and highly aggressive disease. Metastasis-potential and treatment-resistance is thought to rely on increased plasticity of the cancer cells-a mechanism whereby cancer cells alter …
Read PDF<h4>Motivation</h4>Human epigenomic data has been generated by large consortia for thousands of cell types to be used as a reference map of normal and disease chromatin states. Since epigenetic data contains potentially identifiable information, similarly …
Read PDFTumor-derived circulating cell-free DNA (ctDNA) has emerged as a pivotal biomarker for non-invasive cancer diagnosis, treatment monitoring, and prognostic evaluation. However, its inherently low abundance, high fragmentation, and rapid degradation impose stringent requirements on assay …
Read PDF<h4>Background</h4>Understanding how overweight and obesity impact quality of life, psychological well-being, and social functioning is essential for informing and optimizing patient-centric disease management strategies.<h4>Aims</h4>This study aims to investigate the humanistic burden of excess body weight …
Read PDFAging, a major risk factor for numerous diseases, is associated with significant transcriptional changes across organs. However, the age of onset, extent of transcriptomic changes and how they unfold are not fully understood. We performed …
Read PDFChromatin accessibility quantitative trait locus (caQTL) studies have identified regulatory elements that underlie genetic effects on gene expression and metabolic traits. However, caQTL discovery has been limited by small sample sizes. Here, we map caQTLs …
Read PDFTobacco use, alcohol consumption, and infection with human papilloma virus (HPV) are well-established risk factors for head and neck squamous cell carcinomas (HNSCC). However, the incidence of oral cancer, particularly in the mobile tongue, has …
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Read PDFFuchs' endothelial corneal dystrophy (FECD) is a progressive eye disease characterized by accelerated loss of endothelial cells and the development of focal excrescence (guttae) on Descemet's membrane, resulting in cornea opacity and vision deterioration. The …
Read PDFAllergic diseases are a significant global health concern. These disorders result from abnormal immune responses to environmental allergens, influenced by genetic, environmental, and epigenetic factors. Among these, histone acetylation has emerged as a key epigenetic …
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