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Sarcandra glabra (Thunb.) Nakai, a member of the family Chloranthaceae, has a rich history of use in traditional Chinese medicine. To date, >400 compounds have been isolated and characterized from this plant. Studying the genome …
Read PDFBACKGROUND: After the first case of COVID-19 was reported in Côte d’Ivoire in March 2020, the virus spread significantly, with several epidemic waves. During a carriage study conducted from November 2020 to April 2021 to …
Read PDFBACKGROUND: Since 2019, Cameroon has reported a high number of seasonal influenza cases caused by the A(H1N1)pdm09 subtype, which remained the predominant global strain as of 2024. METHODS: To characterize the evolutionary dynamics of circulating …
Read PDFPorcine biomedical models have emerged as valuable tools in biomedical research due to their physiological, anatomical, metabolic, immunological, and genetic similarities to humans. As a result, they offer greater relevance for translational studies than rodent …
Read PDFCarbapenemase-producing Enterobacterales (CPE) are a major public health concern. Within the <i>Enterobacter cloacae</i> complex (ECC), the <i>bla</i><sub>VIM-1</sub> carbapenemase gene is frequently plasmid-borne, enabling inter-clonal and inter-species spread that complicates the detection and control of carbapenemase …
Read PDFLong COVID or Post-Acute Sequelae of SARS-CoV-2 Infection (PASC), marked by persistent symptoms lasting weeks to months after acute SARS-CoV-2 infection, affects multiple organ systems including the respiratory, cardiovascular, neurological, gastrointestinal, and renal systems. These …
Read PDFHere, we report the resequencing, assembly, and annotation of two actinomycete genomes containing abyssomicin gene clusters. <i>Kutzneria buriramensis</i> DSM 45791 with a circular chromosome of 11,681,598 bp and 4 circular plasmids (14,175-207,548 bp) and <i>Streptomyces</i> …
Read PDFReconstructing exact haplotypes is important when sequencing a mixture of similar sequences. Long-read sequencing can connect distant alleles to disentangle similar haplotypes, but handling sequencing errors requires specialized techniques. Here, we present <i>devider</i>, an algorithm …
Read PDF<h4>Background</h4>Hao-Fountain syndrome (HAFOUS) is a rare neurodevelopmental disorder caused by pathogenic variants in the <i>USP7</i> gene. This condition is associated with a distinct DNA methylation episignature that aids its diagnosis. While microarray-based methods have traditionally …
Read PDFThe assembly of insect mitochondrial genomes remains challenging in certain taxa due to extreme AT biases and long repetitive regions. The family Diaspididae (Hemiptera: Coccomorpha) exemplifies this difficulty; despite more than 2,700 described species worldwide, …
Read PDFShort-read metabarcoding analysis is the gold standard for accessing partial 16S and ITS genes with high read quality. With the advent of long-read sequencing, the amplification of full-length target genes is possible, but with low …
Read PDFThe Cape Floristic Region, a biodiversity hotspot in South Africa, is characterised by acidic, nutrient-poor soils and distinctive fynbos vegetation. Despite the ecological importance and metabolic versatility of Acidobacteriota, their diversity and functional roles in …
Read PDF<i>Mannheimia haemolytica</i> is a pathobiont bacterium of the upper respiratory tract in cattle and is associated with acute bovine respiratory disease (BRD). Despite research into bacterial pathogens and their associations with BRD, little is known …
Read PDF<b>Background/Objectives:</b> The emergence of antimicrobial-resistant (AMR) pathogens in aquaculture ecosystems poses a significant risk to both food security and human health. <i>Shewanella</i> species are recognized as significant AMR reservoirs, yet their prevalence and resistance mechanisms …
Read PDFRestriction-modification (RM) systems are widespread defense mechanisms in prokaryotes that protect the host from potentially harmful foreign DNA. They typically consist of a DNA methyltransferase (MTase), which methylates the host genome at an adenine (6 …
Read PDFThe growing resistance of <i>Enterobacterales</i> to last-resort antibiotics such as carbapenems puts a significant burden on healthcare systems, also due to plasmids driving a rapid spread of carbapenem resistance. We here evaluate the use of …
Read PDFIn this work, Oxford Nanopore sequencing is tested as an accessible method for quantifying heterogeneity of amplified DNA. This method enables rapid quantification of deletions, insertions, and substitutions, the probability of each mutation error, and …
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Read PDF<h4>Objective</h4>Multiple-Locus Variable Number of Tandem Repeats (VNTR) Analysis (MLVA) is widely used to subtype pathogens causing foodborne and waterborne disease outbreaks. The MLVAType shiny application was previously designed to extract MLVA profiles of Vibrio cholerae …
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