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GEMS presents a framework for transforming genomic observations into traceable, reproducible, and auditable evidence for regulatory decision-making. It defines an eleven-stage lifecycle, six evidentiary pillars, and the Genomic Evidence Standard (GES), demonstrated through a portable …
Read PDF<b>Aim:</b> Promoter methylation of LINE-1 may be affected by prematurity, but there is little evidence in the literature.<b>Materials & methods:</b> Blood from premature and full-term neonates on days 0, 5, 30 and 90 was analyzed …
Read PDFObesity is a chronic, heterogeneous, and complex disease associated with increased morbidity, mortality, and health-care costs. By 2030, 1 in 2 people in the United States will have obesity. Lifestyle interventions are the cornerstone of …
Read PDFEarly detection of colorectal cancer (CRC) via population-based screening programs can reduce incidence and mortality. Current screening approaches are limited by cost, accessibility, compliance, and colonoscopy capacity. Blood-based screening of circulating tumor (ct) DNA may …
Read PDF<h4>Background</h4>Depression is one of the most common mental disorders that affects >300 million people worldwide. There is a shortage of providers trained in the provision of mental health care, and the nursing workforce is essential …
Read PDFColorectal cancer (CRC) continues to rank among the deadliest and most prevalent cancers worldwide, necessitating an innovative and comprehensive approach that addresses this serious health challenge at various stages, from screening and diagnosis to treatment …
Read PDFColorectal cancer (CRC) is one of the most common and deadliest cancers worldwide, and incidence rates are rising. However, early detection and intervention can improve the survival rates and quality of life of affected patients. …
Read PDFRibosomal RNA (rRNA) synthesis is intricately tied to cellular growth and proliferation. Basic fibroblast growth factor (FGF2), a pivotal factor for bone marrow mesenchymal stem cells (BMSCs), can stimulates rRNA transcription, though the underlying mechanism …
Read PDF<h4>Background</h4>Follicular development is a prerequisite for vertebrate reproduction, and it is precisely regulated by complex genomic conformations and regulatory elements. However, the dynamic changes in the interaction between the three-dimensional genome and regulatory elements of …
Read PDF<h4>Purpose</h4>To summarize current challenges in rare disease (RD) diagnosis and therapy, highlight recent advances in artificial intelligence (AI) for RDs, and propose a model future state for RD patient care.<h4>Methods</h4>Multidisciplinary expert-led narrative review summarizing modern …
Read PDFParkinson's disease (PD) is more prevalent in men than women, and presents with different clinical features in each sex. Despite widespread recognition of these differences, females are under-represented in clinical and experimental studies of PD, …
Read PDF<h4>Abstract</h4>Acute myeloid leukemia (AML) with the t(7;12)(q36;p13) translocation occurs only in very young children and has a poor clinical outcome. The expected oncofusion between break point partners (motor neuron and pancreas homeobox 1 [MNX1] and …
Read PDF<h4>Background</h4>Low vitamin D (vitD) levels are consistently associated with an increased risk of depression. However, the biological mechanisms underlying this relationship and potential shared genetic overlap remain elusive.<h4>Methods</h4>We investigated the genetic overlap and causal relationships …
Read PDFNo one is perfect, and this is particularly true of disease classifications. When diseases are classified according to different dimensions (topography, symptoms, morphology, aetiology, etc), some characteristics of the diseases are prioritised while others are …
Read PDFExposure to immune stress or lipopolysaccharide (LPS) during critical developmental stages like puberty may lead to gut microbiome dysbiosis and epigenetic dysregulation in mammary glands, affecting gene expression and potentially elevating breast cancer susceptibility in …
Read PDF<b>Background/Objectives:</b> Hidradenitis suppurativa (HS) is a complicated chronic inflammatory skin disorder characterized by recurrent and painful deep-seated nodules, abscesses, fistulae, scarring, and sinus tracts. HS most commonly affects high-density hair follicles and apocrine gland-rich regions …
Read PDF<h4>Background</h4>Multi-epitope vaccines have become the preferred strategy for protection against infectious diseases by integrating multiple MHC-restricted T-cell and B-cell epitopes that elicit both humoral and cellular immune responses against pathogens. Computational methods address various aspects …
Read PDF(1) Precision Nursing (PN) emerges as an innovative field within Nursing. (2) PN represents the shift from standardized care to a highly tailored approach. (3) Nursing is strategically positioned to lead the translation of these …
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