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A significant subset of Neuromyelitis Optica Spectrum Disorder (NMOSD) cases occurs as a paraneoplastic syndrome, where an underlying tumor triggers a devastating autoimmune attack against the central nervous system. This autoimmune response is driven by …
Read PDFSingle-cell mapping of chromosomal accessibility patterns has recently led to improved predictive modelling of epigenomic activity from sequence. However, quantitative models explaining the epigenome using directly interpretable components are still lacking. Here we develop IceQream …
Read PDFAdvanced genomics, transcriptomics, and epigenomics techniques are providing unprecedented insights into the understanding of the molecular underpinnings of the central nervous system, including the neuro-sensory cochlea of the inner ear. Here, we report for the …
Read PDFThe heterogeneity of the hematopoietic system was largely veiled by traditional bulk sequencing methods, which measure the averaged signals from mixed cellular populations. In contrast, single-cell sequencing has enabled the direct measurement of individual signals …
Read PDFThis review explores the alterations in natural killer (NK) cell function in acute myeloid leukemia (AML) and their implications for disease progression and therapeutic outcomes. As key effectors of innate immunity, NK cells are critical …
Read PDFLiver macrophages are central in maintaining hepatic homeostasis and mediating immune responses during liver injury, including fibrosis. Macrophages may have proinflammatory or antiinflammatory properties, but which properties influence fibrosis remains unclear. To explore the role …
Read PDFThe development of vaccines against viral infections has advanced rapidly over the past century, propelled by innovations in laboratory and molecular technologies. These advances have expanded the range of vaccine platforms beyond live-attenuated and inactivated …
Read PDFChronic kidney disease (CKD) is a major worldwide health concern because of its progressive nature and complex biology. Traditional diagnostic and therapeutic approaches usually fail to account for disease heterogeneity, resulting in low efficacy. Precision …
Read PDFBiliary tract cancer (BTC) is a highly heterogeneous and aggressive gastrointestinal malignancy, marked by a high mortality rate and limited treatment efficacy. The primary contributing factors include the absence of reliable early detection methods, the …
Read PDFVirus infections in plants are a major threat to crop production and sustainable agriculture, which results in significant yield losses globally. The past decade has seen the development and deployment of sophisticated high-throughput omics technologies …
Read PDFOrgan transplantation remains the definitive therapy for end-stage organ failure, yet its long-term success is limited by allograft rejection. Conventional immunosuppressive regimens, while effective against acute rejection, are hampered by non-specific mechanisms that lead to …
Read PDFOn October 22nd, 2025, Brain Aging Symposium took place at Harvard Medical School bringing together leading researchers from academia and partner organizations to discuss recent advances in measuring and monitoring human brain aging trajectories, with …
Read PDFImmune checkpoint inhibitors (ICIs) can cause immune-related adverse events (irAEs), with acute interstitial nephritis (ICI-AIN) being the most common irAE. While the exact mechanism remains unclear, upregulation of IFN-γ and TNF-α pathways has been implicated. …
Read PDFCancer stem cells (CSCs) represent a critical subpopulation within tumors, driving malignancy, metastasis, and therapeutic resistance. Their unique biological attributes, particularly the distinctive landscape of surface glycans and glycoproteins, offer promising avenues for targeted therapeutic …
Read PDFNeurodevelopmental disorders (NDDs), including autism spectrum disorder, intellectual disability, and attention-deficit/hyperactivity disorder, are genetically and phenotypically heterogeneous conditions affecting millions worldwide. High-throughput omics technologies-transcriptomics, proteomics, metabolomics, and epigenomics-offer a unique opportunity to link genetic variation …
Read PDFInsects represent powerful experimental systems for investigating host-microorganism interactions, providing valuable insights into bacterial pathogenicity, immune regulation, symbiosis, and antimicrobial discovery. This review examines the complex relationships between insects and bacteria, focusing on the mechanisms …
Read PDFThe detection and retrieval of specific single cells within a cell population is useful for elucidating cellular function as well as early-stage cancer diagnosis by detecting circulating tumor cells. Microcapillaries are used to retrieve specific …
Read PDFThe circadian clock drives rhythmic physiological variations, making accurate clock-phase measurement essential. Single-sample phase inference from bulk RNA is an exciting alternative to time-series methods, but its applicability to single cells remains unclear. Using multiplexed …
Read PDFRare cell heterogeneity significantly impacts diagnosis, prognosis, therapeutic options and responses, particularly in diverse diseases like cancer. While single-cell analysis is the most effective route, isolating cells individually with high selectivity, purity, efficiency and throughput …
Read PDFSubchondral bone marrow lesions (BMLs) constitute a pathognomonic imaging feature of both incipient and progressive osteoarthritis (OA). However, the pathological features and molecular mechanisms underlying BMLs remain poorly characterized. Here, we innovatively established and dynamically …
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