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Tuberculosis-diabetes mellitus (TB-DM) is increasingly recognized as a syndemic in which chronic metabolic dysregulation amplifies tuberculosis severity, delays treatment response, and increases relapse and mortality. However, conventional systemic correlates soluble cytokines and bulk whole-blood transcriptomic …
Read PDF<h4>Background</h4>Acute-on-chronic liver failure (ACLF) is a life-threatening syndrome involving dysfunction of multiple immune cell types.<h4>Objective</h4>This study aimed to comprehensively depict the dynamic trajectory of immune responses throughout the disease course of HBV-related ACLF (HBV-ACLF).<h4>Design</h4>Single-cell RNA …
Read PDFThe rapid development of updated and new commercially available single-cell transcriptomics platforms provides users with a range of experimental options. Cost, sensitivity, throughput, flexibility, and ease of use all influence the selection of an optimal …
Read PDFIschemic stroke (IS), a predominant cerebrovascular disorder contributing to global disability and mortality, characterizes by a complex, multi-tiered cascade of pathological processes. As the primary innate immune cells within the central nervous system (CNS), microglia …
Read PDFLocally enhanced electric field treatment (LEEFT) inactivates bacteria via charge-dependent transport into localized high-field regions, requiring resolution of surface-charge heterogeneity rather than population-averaged zeta potentials. Here, we develop a high-throughput single-cell tracking platform to quantify …
Read PDF<h4>Background</h4>Psoriasis, an immune-mediated systemic inflammatory disease affecting skin, vessels, and joints, often co-occurs with depression. Routine depression screening is vital, as mood disorders link to inflammation, visible lesions, and functional limitations.<h4>Methods</h4>The study integrated Mendelian randomization …
Read PDFThe refractoriness of persistent infections to antibiotics necessitates lengthy treatment regimens to prevent therapeutic failures and relapses. Persistence has been attributed to entry of a small fraction of bacterial cells into a slowly growing or …
Read PDFBladder cancer exhibits marked cellular heterogeneity, which complicates the identification of molecular drivers with both functional and genetic relevance. The link between genetic susceptibility and transcriptional activity in tumorigenesis remains incompletely understood. Single-cell transcriptomes of …
Read PDF<i>Clostridium</i> species and yeast single-cell protein (SCP), produced via industrial fermentation, offer a sustainable, high-protein alternative to conventional sources while advancing circular economy goals through CO<sub>2</sub> valorization. Here, we developed an integrated two-stage bioprocess for …
Read PDFStem cell-derived models are a powerful tool for studying biology and are increasingly paving the way for cell-based therapies. However, understanding precisely which cell types are present and how closely they recapitulate in vivo cells …
Read PDFInsomnia is closely associated with immune dysregulation, yet the overall pattern of peripheral-central immune disequilibrium and its underlying molecular basis remains incompletely understood. To characterize the peripheral-central immune features associated with insomnia, identify key immune …
Read PDFSingle-cell sequencing is a novel approach to genome sequencing of clinical samples. However, there are only few studies using single-cell sequencing of genomes for bacterial infections. A 71-year-old woman presented to the emergency department with …
Read PDF<h4>Background</h4>Chronic lymphocytic leukemia (CLL) develops from physiologic B cells through low- and high-count monoclonal B cell lymphocytosis (LC-/HC-MBL). The timing and nature of early B cell expansion and molecular evolution remain unclear, limiting prediction of …
Read PDFUnderstanding how individual cancer cells adapt to drug treatment is a fundamental challenge limiting precision medicine cancer therapy strategies. Here, we present a multimodal framework that integrates bulk and single-cell treated and untreated transcriptomics data …
Read PDFEggshell quality is a major concern in the poultry industry. The speckle phenotype in eggshell affects eggshell color, thickness, and Haugh Unit (HU) and significantly affects the hatchability rate. The rate of speckled eggs increases …
Read PDFNeuropsychiatric Systemic Lupus Erythematosus (NPSLE) represents one of the most severe and enigmatic manifestations of SLE, contributing significantly to disease morbidity and mortality. Its clinical presentation is profoundly heterogeneous, encompassing 19 distinct syndromes that pose …
Read PDF[This corrects the article DOI: 10.3389/fimmu.2026.1744845.].
Read PDFBACKGROUND: Adenomyosis (AM) is a common gynecological disorder in reproductive-age women, with impaired endometrial receptivity as a key contributor to infertility. However, a comprehensive single-cell atlas of the eutopic endometrium during the implantation window remains …
Read PDFUnderstanding how genetic risk variants contribute to respiratory diseases requires mapping genome-wide association study (GWAS) signals to disease-relevant cell types and states within the human lung. Here, we integrated GWAS summary statistics for ten major …
Read PDF<h4>Background</h4>Multiple myeloma (MM) typically evolves from monoclonal gammopathy of undetermined significance (MGUS) and smoldering multiple myeloma (SMM). Its progression is accompanied by significant tumor heterogeneity and immune microenvironment remodeling, and MM remains largely incurable despite …
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