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Intratumor heterogeneity (ITH) is a fundamental driver of therapeutic failure and disease progression. However, the complexity of the tumor ecosystem is a critical yet underexplored aspect, making its precise quantification essential for fully deciphering ITH …
Read PDFRheumatoid arthritis (RA) is a chronic autoimmune inflammatory disorder marked by joint swelling, pain, and progressive tissue destruction. Increasing evidence suggests that dysregulated RNA expression critically drives RA progression by perturbing immune, inflammatory, and stromal …
Read PDF<h4>Background</h4>Long-term survival of lung transplant recipients remains limited by chronic lung allograft dysfunction (CLAD). CLAD is only diagnosed following a persistent and substantial decline in lung function, after which irreversible damage to the lungs has …
Read PDFThe ability to resolve rare and transient cellular states is critical for understanding metastasis, immune evasion, and therapy resistance in cancer, yet these dynamic processes often escape detection by conventional sequencing and imaging approaches. Recent …
Read PDF<h4>Background</h4>Nasopharyngeal carcinoma (NPC) is associated with aberrant cellular metabolism and interactions between tumor and stromal cells. This study aims to elucidate the role of glycerophospholipid metabolism in NPC, particularly focusing on the interplay between malignant …
Read PDFSpatial transcriptomics analysis is a powerful approach for dissecting the structure of tissue microenvironment and uncovering the mechanism of cell-cell communications. However, existing technologies are limited by either spatial resolution or gene coverage. Most single-cell-resolution …
Read PDFAlzheimer's disease (AD) is a complex neurodegenerative disorder that is associated with cognitive decline in the elderly. While β-amyloid (Aβ) plaques and neurofibrillary tau tangles have been used to define and stage AD onset in …
Read PDFComplex microorganisms are the drivers of fermentation ecosystem and play a pivotal role in determining product yield and quality. Although significant efforts have been devoted to characterizing microbial composition and diversity, these cannot fully elucidate …
Read PDFAbrothrix olivacea (Waterhouse, 1837), the olive grass mouse, is a widely distributed sigmodontine rodent that inhabits a broad range of environments, from the hyper arid deserts of southernmost Perú and northern Chile to the Patagonian …
Read PDF<h4>Background and objective</h4>The cellular distribution characteristics and functional mechanisms of glutathione (GSH) metabolism within the tumor microenvironment (TME) of glioblastoma multiforme (GBM) remain poorly understood. This study aims to elucidate the cellular landscape and GSH …
Read PDFArtificial intelligence (AI) is increasingly used in cancer research, enabling integrative analysis of complex biomedical data to identify actionable therapeutic vulnerabilities. This review specifically examines how AI advances mechanistic cancer target discovery and translational drug …
Read PDFEpstein-Barr virus (EBV) infection has been studied at single-cell resolution for six decades and counting. Such investigations can reveal virus-host interactions and their dependence on viral strain, cellular niche, infection program, immune response regulation, and …
Read PDFThe integration of single-cell genomics into the chemical genetics paradigm is reshaping how researchers profile drug activity, prioritize lead candidates, and uncover new therapeutic opportunities. Traditional chemical genetic approaches, though instrumental in linking compounds to …
Read PDFDeep learning frameworks have been developed for interpreting single-cell RNA sequencing (scRNA-seq) data and have demonstrated excellent performance across a range of tasks. However, existing methods remain limited in their ability to characterize heterogeneity at …
Read PDFSingle-cell RNA sequencing (scRNA-seq) is a powerful tool for characterising the immune landscape. Multiple technologies are available, each with distinct specificities and inherent biases. Here, we focus on two technologies-10X Genomics and Parse Biosciences-for the …
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