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Over the past century, studying the human brain has been one of the most complex and enduring biological challenges. Initial approaches, ranging from gross neural anatomy to cellular subtype organization, have significantly advanced our understanding …
Read PDFEstrogen receptor-positive breast cancer progression involves extensive cellular remodeling, yet the contribution of RNA-binding proteins to this process remains incompletely defined. Here, we constructed a single-cell transcriptomic atlas of 198,286 cells from 39 samples spanning …
Read PDFSeeds provide 70% of the global food supply, making them crucial for food security. Understanding the molecular mechanisms governing seed development, dormancy, and germination has become increasingly urgent as climate change impacts crop productivity. Over …
Read PDFTriaptosis, an emerging form of cell death, remains poorly characterized in terms of its heterogeneity within clear cell renal cell carcinoma (ccRCC). Utilizing single-cell transcriptomics, we delineate a landscape of triaptosis heterogeneity and identify monocytes …
Read PDF<h4>Background</h4>POU5F1 (OCT4), a core regulator of pluripotency, plays an important role in tumor stemness and immune microenvironment remodeling, yet its systematic function and mechanisms in lung adenocarcinoma (LUAD) remain incompletely elucidated.<h4>Methods</h4>This study integrated genetic causality …
Read PDF<h4>Objective</h4>This study aims to explore how the tumour microenvironment influences the aggressiveness, malignancy, and recurrence of ameloblastoma. By employing a spatial omics approach, we will examine the characteristics of the invasive front of ameloblastoma.<h4>Methods</h4>We systematically …
Read PDFSpatial transcriptomics (ST) enables genome-wide gene expression profiling while preserving tissue architecture, bridging the gap between bulk, single-cell, and histological analyses. Originating in 2016 and rapidly evolving since, ST has transformed infectious disease research by …
Read PDFBACKGROUND: Spatial and temporal intratumoral heterogeneity (ITH) remains a major challenge in the diagnosis, prognosis, and treatment of breast cancer. Recent advances in single-cell and spatial omics technologies have enabled unprecedented resolution of subclonal architectures, …
Read PDFThe traditional paradigm of linking single genes to individual phenotypes is being replaced by a systems-level framework to understand the complexity of the tumor microenvironment. In this context, in silico knockout has emerged as a …
Read PDFCelcomen leverages a mathematical causality framework to disentangle intra- and inter-cellular gene regulation programs in spatial transcriptomics data through a generative graph neural network. It is a first step towards perturbation models of Virtual Tissues …
Read PDFSpatial transcriptomics technologies profile gene expression across tissue sections while retaining spatial information, yet most platforms capture signals from multiple cells per measurement location, requiring computational methods to determine the underlying cellular composition. Current deconvolution …
Read PDF<h4>Introduction</h4>To establish a dynamic metabolic subtyping system for acute myeloid leukemia (AML) based on longitudinal metabolomics and multi-omics integration, and to evaluate its ability to predict treatment response.<h4>Methods</h4>We enrolled 29 AML patients and performed untargeted …
Read PDFPancreatic neuroendocrine tumors (PNETs) represent a biologically heterogeneous group of neoplasms shaped by both intrinsic genomic alterations and dynamic interactions with the tumor microenvironment (TME). Conventional analytical approaches offered limited insight into these complex mechanisms. …
Read PDFNeuroblastoma is the most common extracranial solid tumor in children, presenting significant challenges in diagnosis and treatment due to its highly heterogeneous clinical manifestations and complex genetic background. In recent years, advances in transcriptomics have …
Read PDFOsteosarcoma (OS), the most frequent primary malignant bone tumor in children and adolescents, is characterized by substantial inter- and intra-tumoral heterogeneity and an immunosuppressive tumor microenvironment (TME), constraining the efficacy of both standard chemotherapy and …
Read PDFChina has rich bamboo resources, with Moso bamboo (<i>Phyllostachys edulis</i>) being the most economically important species. Bamboo shoot bud development directly determines the eating quality of the shoots and the properties of bamboo materials; however, …
Read PDFThe human body contains ~27-37 trillion cells of up to 10,000 cell types (CTs) within a volume of ~62-120 liters (males) and 52-89 liters (females). The Human Reference Atlas (HRA) v2.3 provides a quantitative 3D …
Read PDFThe brain is sustained by an intricate vascular network that provides a continuous supply of nutrients and oxygen essential for its function. Understanding the structural variability and region-specific function of this neurovascular system is essential …
Read PDFMetastasis formation is classically considered a late-stage event in colorectal cancer evolution. Yet the time and spatial patterning by which metastatic competence is acquired remain poorly understood<sup>1,2</sup>. Here we show that metastasis-associated oncofetal cell states …
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