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<b>Objective:</b> To elucidate the role of cytoskeleton-associated protein 2 (CKAP2) in gastric cancer (GC) progression and evaluate its prognostic and potential protective significance. <b>Methods:</b> The candidate genes for GC were identified using differential expression and …
Read PDFBACKGROUND: Migraine and Meniere’s disease (MD) show high clinical comorbidity, shared symptoms such as vertigo and overlapping mechanisms like neurogenic inflammation suggest common pathophysiology. However, the core immunogenetic drivers underlying this comorbidity, particularly at cellular …
Read PDFSingle-cell technologies have revolutionized the understanding of cellular heterogeneity, revealing distinct cell populations and functional states with molecular precision. Traditional approaches, however, are constrained by cellular dimension and throughput scale, in addition to its inability …
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Read PDFLegumes are important food crops and play a central role in sustainable agriculture through their ability to form symbiosis with rhizobia, soil bacteria that fix atmospheric nitrogen. Recent advances in single-cell and spatial transcriptomics, along …
Read PDF<h4>Motivation</h4>Single-cell omics analysis has unveiled the heterogeneity of various cell types within tumors. However, no methodology currently reveals how this heterogeneity influences cancer patient survival at single-cell resolution. Here, we introduce scSurv, combining a Cox …
Read PDFSingle-cell Assay for Transposase-Accessible Chromatin using sequencing (scATAC-seq) has emerged as a powerful technique to study cell-specific epigenetic landscapes and to provide a multidimensional portrait of gene regulation. However, low genomic coverage per cell results …
Read PDF<h4>Objectives</h4>Oligoarticular JIA (oligo JIA) is the most common JIA subtype and is often complicated by uveitis, a potentially sight-threatening comorbidity. Despite its prevalence, the immunopathogenic mechanisms underlying oligo JIA and its extra-articular manifestations remain poorly …
Read PDF<i>In vitro</i> kidney models play a crucial role in the study of renal development, (patho)physiology, drug development, and potential applications in bioartificial kidneys. Human <i>in vitro</i> kidney models have recently advanced significantly with the development …
Read PDFRecent advancements in single-cell genomic and transcriptomic sequencing, in situ sequencing, and molecular imaging-based technologies have facilitated the examination of heterogeneity within microbial communities at the single-cell level. These cutting-edge methodologies permit the capture of …
Read PDFLymphatic malformations (LMs) are debilitating and potentially life-threatening diseases. However, the immune phenotype of circulating cells and underlying molecular mechanisms in LMs remain poorly understood. Here, we performed integrated single-cell RNA, T-cell receptor, and B-cell …
Read PDFUnderstanding how to effectively treat neurological deficits after stroke remains difficult, as both the therapeutic targets and clinical outcomes are still uncertain. Although intermittent Theta burst stimulation (iTBS) has recently been shown to protect neural …
Read PDFBulk RNA sequencing (RNA-seq) deconvolution typically uses single-cell RNA sequencing (scRNA-seq) references, but some cells are only detectable through single-nucleus RNA sequencing (snRNA-seq). Because snRNA-seq captures nuclear, not cytoplasmic, transcripts, its direct use as a …
Read PDF<h4>Background</h4>Cutaneous melanoma is a highly aggressive malignancy characterized by significant heterogeneity, rapid progression, and variable treatment responses. Understanding the functional diversity of melanoma cells and their interactions with the tumor microenvironment (TME) is crucial for …
Read PDFDuring mouse development, hematopoietic stem and progenitor cells (HSPCs) originate from hemogenic endothelial cells (ECs) through a process of endothelial-to-hematopoietic transition. These HSPCs are thought to fully sustain adult hematopoiesis. However, it remains unknown whether …
Read PDF[This corrects the article DOI: 10.1371/journal.pcbi.1011288.].
Read PDF<h4>Background</h4>The emergence of single-cell RNA sequencing (scRNA-seq) technology has revolutionized our capacity to study cell functions in complex tissue microenvironments. Traditional transcriptomic approaches, such as microarrays and bulk RNA sequencing, lacked the resolution to distinguish …
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