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Renal cell carcinoma (RCC) exhibits marked heterogeneity in its molecular landscape and clinical behavior. Ferroptosis, an iron-dependent and lipid peroxidation-driven form of cell death, has emerged as a biologically relevant process in RCC pathogenesis. This …
Read PDFDifferential accessibility (DA) analysis of single-cell epigenomics data enables the discovery of regulatory programs that establish cell type identity and steer responses to physiological and pathophysiological perturbations. While many statistical methods to identify DA regions …
Read PDFIn recent years, with the continuous development of single-cell sequencing (sc-seq) technology, Sc-seq can conduct high-throughput and high-resolution transcriptome analysis at the single-cell level, revealing gene expression differences and molecular characteristics among individual cells. This …
Read PDF<h4>Background</h4>Chronickidney disease (CKD) is a major global health burden lacking effectivetherapies. Renal interstitial fibrosis (RIF) is a key pathological driver ofCKD progression. This study aimed to identify novel diagnostic biomarkers and therapeutictargets.<h4>Research design and methods</h4>Weanalyzed …
Read PDFIntegrating bioinformatics tools has profoundly transformed precision oncology by identifying essential molecular targets for personalized treatment. The rapid development of high-throughput sequencing and multiomics technologies creates complex datasets that require robust computational methods to extract …
Read PDFCancer risk increases with age, and cellular senescence may be a major contributor to cellular carcinogenesis. Enormous efforts have been made to investigate the interrelation between aging and tumors, but little is known about the …
Read PDFIdentifying drivers of cancer progression to guide treatment selection is hindered by our limited understanding of tumor heterogeneity and its impact on tumor evolution. Here, we delineate the phenotypic variability across ~300,000 cells collected from …
Read PDFImmune checkpoint inhibitors (ICIs) have transformed oncology, yet durable benefit remains confined to a minority of patients, revealing the limitations of single biomarkers such as PD-L1 expression, tumor mutational burden, and microsatellite instability. Multi-omics profiling, …
Read PDFThe integration of artificial intelligence (AI) into next-generation sequencing (NGS) has revolutionized genomics, offering unprecedented advancements in data analysis, accuracy, and scalability. This review explores the synergistic relationship between AI and NGS, highlighting its transformative …
Read PDFThe rapid evolution of single-cell sequencing technologies has significantly advanced our knowledge of cellular heterogeneity and the underlying molecular basis in healthy and diseased kidneys. While single-cell transcriptomic analysis excels in characterizing cell states in …
Read PDFArtificial intelligence (AI) excels at efficiently processing large volumes of data and extracting valuable insights. Deep Learning (DL), a subfield of AI, utilizes multi-layer neural network algorithms to analyze various types of data, mimicking the …
Read PDFPost-translational modifications (PTMs) form a sophisticated regulatory layer that modulates cellular responses to physiological stimuli, notably exercise-triggered metabolic adaptations like skeletal muscle glucose uptake. Understanding PTM-mediated regulatory logic, namely how several well-characterized PTMs coordinate spatiotemporally …
Read PDFNonsyndromic orofacial clefts (NSOC) are common congenital craniofacial developmental defects. Current evidence suggests that genetic factors, environmental exposures, and their interactions jointly contribute to the development of the disease. Owing to the high heritability of …
Read PDFAge-related hearing loss is a prevalent and growing public health issue among the elderly. Here, we perform a multi-ancestry genome-wide association study comprising 456,613 cases and 1,053,834 controls, identifying 140 independent loci associated with age-related …
Read PDFGliomas are among the most malignant and aggressive tumors of the central nervous system, characterized by the absence of early diagnostic markers, poor prognosis, and a lack of effective treatments. Advances in high-throughput technologies have …
Read PDFStress is often described as a fleeting feeling, a momentary surge of tension or anxiety, but in my work as a neurobiologist, I have come to understand it as something far more enduring and complex. …
Read PDFCancer immunotherapy has revolutionized clinical oncology; however, the inherent complexity and heterogeneity of cancer present substantial challenges to achieving broad therapeutic efficacy. Tumor heterogeneity manifests not only among different patients but also within individual tumors, …
Read PDFRapid advancement of sequencing technologies now allows for the utilization of precise signals at single-cell resolution in various omics studies. However, the massive volume, ultra-high dimensionality, and high sparsity nature of single-cell data have introduced …
Read PDFDiabetes mellitus (DM) comprises distinct subtypes-including type 1 DM, type 2 DM, and gestational DM - all characterized by chronic hyperglycemia and substantial morbidity. Conventional diagnostic and therapeutic strategies often fall short in addressing the …
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