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Childhood is a critical period for hematopoietic development and susceptibility to hematologic disease. Here we generated a multimodal single-cell atlas of healthy human bone marrow, capturing mRNA and surface protein expression in 90,710 cells, including …
Read PDFAdvances in cardiac regenerative medicine increasingly rely on integrating artificial intelligence with spatial multi-omics technologies to decipher intricate cellular dynamics in cardiomyocyte differentiation. This systematic review, synthetising insights from 88 PRISMA selected studies spanning 2015-2025, …
Read PDFHead and neck squamous cell carcinoma (HNSC) is an aggressive malignancy often resistant to therapy, especially in advanced stages. Metabolic reprogramming, marked by shifts in glycolysis and oxidative phosphorylation (OXPHOS), is crucial for tumor progression …
Read PDFMaternal opioid use disorder (OUD) poses substantial risks to maternal and fetal health. These adverse outcomes are believed to be mediated, in part, by changes in placental structure and function; however, few studies have addressed …
Read PDF<h4>Background</h4>Cervical cancer, as one of the most common types of malignant tumors in women, poses a significant threat to the health and survival of women worldwide. Tumor drug resistance has emerged as a critical bottleneck …
Read PDFAmyloid beta (Aβ) plaque deposition in the central nervous system (CNS) is a hallmark of Alzheimer's disease (AD) and cerebral amyloid angiopathy (CAA), triggering robust innate immune responses. However, the role of the adaptive immune …
Read PDFLiver cancer is one of the deadliest malignancies, with increasing incidence worldwide. Recent advances in immunotherapy have expanded the options for systemic therapy against advanced hepatocellular carcinoma (HCC), but there are no biomarkers currently available …
Read PDFUnderstanding the temporal dynamics of gene expression within spatial contexts is essential for deciphering cellular differentiation. RNA velocity, which estimates the future state of gene expression by distinguishing spliced from unspliced mRNA, offers a powerful …
Read PDFSpatial transcriptomics has emerged as a transformative technology in biomedical research, offering unprecedented insights into gene and protein expression within their native tissue context. Unlike conventional bulk or single-cell sequencing approaches, spatial omics has the …
Read PDFImmune checkpoint blockade (ICB) has transformed cancer therapy, but its effect is often limited by immunosuppression and resistance mechanisms within the tumor microenvironment (TME). Cancer-associated fibroblasts (CAFs) represent a major stromal component of the TME. …
Read PDFRecent advances in spatial omics technologies have enabled transcriptome profiling at subcellular resolution. By performing cell segmentation on nuclear or membrane staining images, researchers can acquire single cell level spatial gene expression data, which in …
Read PDFCancer-associated fibroblasts (CAFs) and tumor-associated macrophages (TAMs) are pivotal stromal and immune components of the tumor microenvironment (TME) that orchestrate immune evasion, metabolic reprogramming, and therapeutic resistance. Regions enriched in CAFs are frequently accompanied by …
Read PDFAdvances in single-cell and spatial technologies have transformed the dissection of cell composition and tissue architecture in complex biological systems. However, identifying rare cells critical to disease pathogenesis and biological processes remains difficult, as their …
Read PDFAdvances in organoid and other three-dimensional culture systems, single-cell and spatial transcriptomics, multi-omics, and high-resolution imaging are reshaping our understanding of the cellular origins and evolutionary trajectories of glioblastoma. When integrated with modern data science …
Read PDFNeutrophils are key first responders in the host response to <i>Clostridioides difficile</i> infection (CDI). Although a high number of tissue and blood neutrophils clearly correlates with adverse outcomes in CDI patients, their functional role remains …
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Read PDFAldosterone-producing adenomas (APAs) and micronodules (APMs) are histopathological lesions that can cause a prevalent form of secondary hypertension called primary aldosteronism. Using integrated single-cell/nucleus and spatial transcriptomics, it demonstrates substantial heterogeneity between APMs and APAs, …
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