Search the literature by keyword, topic, or author. Filter to articles with full text available.
1073 results
Studying how microenvironmental cues influence metabolic reprogramming can uncover mechanisms driving tumor progression. Using an in vitro model with proliferative stimuli of the in vivo lymph node niche (LN)-including interleukin-21 (IL-21)-we examined metabolic rewiring in …
Read PDF<h4>Introduction</h4>Sepsis is a life-threatening organ dysfunction syndrome with persistently high global mortality, driven by dysregulated host immune response. Existing single-target therapies fail to simultaneously address hyperinflammation and impaired tissue repair, leading to limited clinical efficacy …
Read PDF<h4>Background</h4>Many patients with cancer benefit little from immune checkpoint blockade (ICB), a major obstacle to immunotherapy for decades. Finding alternative immune checkpoints that control CD8<sup>+</sup> T-cell exhaustion is urgent if we are to improve the …
Read PDFAtherosclerosis is a chronic inflammatory disease of blood vessels, characterized by atherosclerotic lesions in large- and medium-sized arteries. IFNγ is a crucial mediator of atherosclerosis through activation of signal transducer and activator of transcription (STAT)1. …
Read PDFIntegrative analysis of RNA-seq datasets faces critical challenges in disentangling biologically meaningful signals from implicit confounders, such as unmeasured technical variability and nonlinear interactions between biological and technical variables. Traditional methods like Surrogate Variable Analysis …
Read PDF<h4>Introduction</h4>Early-life exposure to general anesthetics has been associated with increased neurodevelopmental vulnerability, but the cell type-resolved mechanisms remain incompletely understood. Here, we investigated whether isoflurane-induced neonatal neurotoxicity is associated with a glia-linked ferroptotic susceptibility state …
Read PDFThe intestinal mucosa is a complex functional layer which is formed from a diverse range of cell types that include epithelial cells (within crypts and villi) and an array of mesenchymal cells. Many intestinal diseases …
Read PDFThe mammalian heart rapidly loses regenerative capacity after birth and responds to myocardial infarction (MI) with scar formation and development of interstitial fibrosis. Cardiac fibroblasts orchestrate extracellular matrix (ECM) remodeling and cell-cell communication during development …
Read PDF<h4>Background</h4>The role of sebaceous glands (SGs) in the early pathogenesis of hidradenitis suppurativa (HS) remains undefined, with an unclear causal relationship to inflammatory sequelae. The aim of this study is to determine whether SG aberrations …
Read PDFNatural killer (NK) cell function within tissues extends beyond exerting cytotoxicity, encompassing a range of functions that are just starting to become fully elucidated. In the context of human placentation, NK cells play a key …
Read PDFCell polarity is essential for maintaining intestinal epithelial organization and function. Here we show that combined loss of polarity by epithelial loss of Cdc42 with oncogenic Kras expression in mice causes small intestine failure leading …
Read PDFYAP1 signaling is essential for development but its specific roles in early embryogenesis remain poorly understood. To shed light on this, we analyze YAP1's role in regulating the pluripotency of the mammalian epiblast, using scRNAseq …
Read PDFThe human heart, originating from the splanchnic mesoderm, is the first functional organ to develop, co-evolving with the foregut endoderm through reciprocal signaling. Previously, cardioid models offered new insights on cardiovascular cell lineages and tissue …
Read PDFAllele-specific expression (ASE) of somatic mutations can be caused by <i>cis</i>-activation of the mutant allele or silencing of the wild-type allele and has been investigated by examining the enrichment of mutant allele in RNA relative …
Read PDF<h4>Background</h4>Papain-like cysteine protease (PLCP), a vital subgroup of peptidases, play crucial roles in various biological processes including plant growth, seed germination, anther development, and stress responses.<h4>Results</h4>In this study, 44 FvPLCP genes were identified through phylogenetic …
Read PDFPrimary cilia are increasingly recognized as regulators of cellular signaling and plasticity. Here, we examined their distribution and potential relevance in neuroendocrine (NE) prostate cancer. While typically absent in localized hormone-sensitive prostate tumor cells, we …
Read PDFDigestive cancers exhibit high heterogeneity and poor prognosis, yet whether their tumor microenvironments share conserved stromal-immune interactions remains unclear. Here, we performed an integrative multi-omics analysis across seven digestive cancer types and identified a conserved …
Read PDFRegulatory circuits driving regional cell fate specification and lineage restriction decisions are not fully understood. The molecular mechanisms by which Hedgehog signaling controls lineage segregation in the posterior foregut remain unclear. Here, we employed bulk …
Read PDFDorsal root ganglion (DRG) neurons have a wide range of functions, including touch, pain and itch. These neurons have recently emerged as promising targets for non-invasive focused ultrasound (FUS) neuromodulation. However, our understanding of the …
Read PDFEndothelial cells (ECs) are crucial in cancer development and progression, partly by regulating tumor angiogenesis and immune modulation. As a key component of the RNA-induced silencing complex, Argonaute 1 (AGO1) regulates tumor biology, yet the …
Read PDF