Search the literature by keyword, topic, or author. Filter to articles with full text available.
1073 results
The growing global protein demand and environmental concerns from conventional animal agriculture have driven the exploration of sustainable alternative protein sources. Single-cell proteins (SCPs) from microbial fermentation offer a promising solution. This study comprehensively evaluated …
Read PDFRegenerative repair of injuries and degenerative diseases in the musculoskeletal system remains a paramount clinical challenge, as conventional single-modal technologies fail to recapitulate the intricate structural and functional complexity of native musculoskeletal tissues. In recent …
Read PDF<h4>Background</h4>The tumor immune microenvironment, containing a variety of immune cells with both tumor-promoting and anti-tumoral functions, plays a significant role in tumor immune surveillance and immunological evasion. Characterizing the landscape of the tumor immune microenvironment …
Read PDFDistinct regional functionality of the human cortex is orchestrated by diverse cellular and molecular processes, yet the underlying regulatory mechanisms remain poorly understood. We performed multiomic single-cell and spatial characterization of nine regions of the …
Read PDF<b>Background</b>: Standard single-cell RNA sequencing (scRNA-seq) analysis workflows face significant limitations, particularly the rigidity of clustering-dependent methods that can obscure subtle cellular heterogeneity and the potential loss of biologically meaningful cells during stringent quality control …
Read PDFTumor-associated B (TAB) cells and plasma cells are increasingly recognized as key components of the tumor microenvironment; however, their heterogeneity and functional roles in breast cancer remain incompletely understood. Here, by integrating publicly available single-cell …
Read PDFSingle-cell RNA-seq data from F1 hybrids provide a unique framework for dissecting complex regulatory mechanisms, but allelic measurements are limited by technical noise due to low counts. Here, we present ASPEN, a statistical method for …
Read PDFPrecise prediction of perturbation responses is essential in systems biology research, as it plays a pivotal role in characterizing cellular identities and elucidating the regulatory mechanisms of biological pathways. Existing perturbation-responses prediction approaches are predominantly …
Read PDFOmics research is changing the way medicine develops new strategies for diagnosis, prevention, and treatment. With the surge of advanced machine learning models tailored for omicss analysis, recent research has shown improved results and pushed …
Read PDF<h4>Background</h4>Previous studies have integrated genome-wide association studies with expression quantitative trait locus (eQTL) data from bulk tissues to identify stroke susceptibility genes. However, eQTL data exhibit high cell-type specificity, and genetic variants may have distinct …
Read PDF<h4>Background</h4>Cirrhosis is a severe liver disease characterized by inflammation, fibrosis, and immune dysregulation. This study exploits publicly available single-cell sequencing datasets to decipher disease-relevant specific immune cell subtypes, their gene expression profiles and altered transcription …
Read PDF<h4>Background</h4>Endometriosis is a chronic estrogen-dependent inflammatory disease that shares epidemiological and pathological features with endometrial cancer. However, the cellular and genetic mechanisms underlying this association remain unclear.<h4>Aim</h4>To investigate the immunological mechanisms underlying endometriosis and endometrial …
Read PDF<h4>Introduction</h4>Population aging is a global demographic shift closely associated with immune dysregulation, which significantly increases the risk of chronic liver diseases. As a crucial immune and metabolic organ, the liver relies on a complex immune …
Read PDFThe 5-year overall survival rate for hepatocellular carcinoma (HCC) patients remains below 20%. Alterations in the extracellular matrix (ECM) are increasingly recognized as central drivers of HCC initiation and progression. This study applied a system …
Read PDFDiabetic foot ulcers (DFU) is severe complications of diabetes mellitus, affecting 15–25% of diabetic patients and imposing substantial healthcare burdens. Lactylation has emerged as a critical regulator in inflammation and wound healing processes. However, the …
Read PDFSkeletal stem cells (SSCs) are well characterized in humans and mice, providing valuable insights into bone development and regeneration. However, their identification in poultry, particularly in chicken embryos, remains limited. In the present study, we …
Read PDF<h4>Background</h4>Macrophages are key regulators within the lung adenocarcinoma (LUAD) tumor microenvironment, and their functional states and interaction patterns are closely linked to prognosis and immunotherapy response. However, macrophage-associated risk models derived from single-cell features remain …
Read PDF